With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36216-80-5,Benzo[d]isoxazol-3-amine,as a common compound, the synthetic route is as follows.,36216-80-5
EXAMPLE 12 3-[(4-pyridinyl)amino]-1,2-benzisoxazole A mixture of 3-amino-1,2-benzisoxazole (9.94 g, 74.18 mmole, prepared according to a method described in G. M. Shutske and K. J. Kapples, J. Heterocyclic Chem., 26, 1293 (1989)), 4-chloropyridine hydrochloride (22.27 g, 197 mmole) and 1-methyl-2-pyrolidinone was stirred vigorously at 130 C. for three hours. The reaction mixture was cooled, diluted with NaHCO3, and extracted with EtOAc, after which the organics were washed with water, dried (MgSO4), and concentrated. The residue was purified by flash chromatography (florisil, EtOAc), and then triturated with diethyl ether to yield 4.04 g (26%) of a fine brown solid. A 2.0 g portion was dissolved in boiling methanol and treated with charcoal (Darco) after which the product crystallized to yield 1.38 g of pale yellow crystals, mp 203 C. (dec.). ANALYSIS: Calculated for C12 H9 N3 O: 68.24% C; 4.29% H; 19.89% N; Found: 68.14% C; 4.12% H; 20.06% N.
The synthetic route of 36216-80-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Incorporated; US5328920; (1994); A;,
Benzisoxazole – Wikipedia
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