Recently I am researching about HUMAN 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE, Saw an article supported by the . Published in KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING in SEOUL ,Authors: Na, AR; Choi, D; Cho, H. The CAS is 90-27-7. Through research, I have a further understanding and discovery of 2-Phenylbutanoic acid. COA of Formula: C10H12O2
The objective of this study was to evaluate the synthesis, structural analysis, and biological effects of novel ((2, 4-dioxothiazolidin-5-ylidene)methyl)phenyl derivatives. The efficacy of 15-PGDH inhibition increased for the substituents in the derivatives in the order: cyclohexylpropyl > cyclohexylethyl > cyclohexylmethyl > cyclohexyl. Compound 12 inhibited 15-PGDH activity by binding to the amino acids Ile 214, Ile 210, Ile 194, Gln 148, and Leu 191 of 15-PGDH. Compounds 4, 22, and 23 produced the highest increment in PGE(2) concentration, which was 122.19, 100.14, and 206.80%, respectively, compared to that of the control. Also, compounds 38 and 39, in which the central phenyl ring and the 2, 4-thiazolidinedione moiety were linked by a single bond, produced a relatively high increment in PGE(2) concentration, which was 106.81 and 118.66%, respectively, compared to that of the control. The wound closure rates of compounds 22 and 39 were the highest, being 247.56 and 202.42%, respectively, compared to that of the positive control. Therefore, compounds 22 and 39 could not only efficiently regulate PGE(2) concentration, but also induce cellular regeneration, and are expected to effectively treat a variety of diseases resulting from PGE(2) deficiency.
COA of Formula: C10H12O2. About 2-Phenylbutanoic acid, If you have any questions, you can contact Na, AR; Choi, D; Cho, H or concate me.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics