Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino-1,3,4-thiadiazoles, the main research direction is amino thiadiazole preparation green ultrasound anticancer activity inhibition; 1 3 4-thiadiazole; PEG-400; SIRT1; cytotoxicity; lemon juice; ultrasound.Name: 2-Furoic hydrazide.
An ultrasound-assisted method facilitated by lemon juice has been developed to synthesize 2-amino-1,3,4-thiadiazole derivatives I (Ar = Ph, 2-methoxy-5-nitrophenyl, pyridin-3-yl, etc.) that could act as potential anticancer agents. Accordingly, a convenient method has been developed for the rapid synthesis of this class of compounds I under a mild and non-hazardous reaction condition in good yields. The methodol. involved the reaction of various acid hydrazides ArC(O)NHNH2 with TMSNCS in the presence of lemon juice in PEG-400 at room temperature (25-30°C) under ultrasound irradiation These compounds I were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g., MDAMB-231 and MCF-7 and subsequently against SIRT1. The 2-amino 1,3,4-thiadiazole derivatives I (Ar = 4-methoxyphenyl, 3-methoxyphenyl, 2,3-dimethoxyphenyl, 2-methoxy-5-nitrophenyl) showed promising growth inhibition of MDAMB- 231 and MCF-7 cell lines and SIRT1 inhibition in vitro. Indeed, I (Ar = 3-methoxyphenyl) was found to be a potent inhibitor of SIRT1.
Here is a brief introduction to this compound(3326-71-4)Name: 2-Furoic hydrazide, if you want to know about other compounds related to this compound(3326-71-4), you can read my other articles.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics