The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. SDS of cas: 3878-55-5, 3878-55-5, Name is 4-Methoxy-4-oxobutanoic acid, SMILES is C(C(OC)=O)CC(O)=O, in an article , author is Vanjari, Rajeshwer, once mentioned of 3878-55-5.
Ring Expansion and 1,2-Migration Cascade of Benzisoxazoles with Ynamides: Experimental and Theoretical Studies
Demonstrated herein is an Au-I-catalyzed annulation of sulfonyl-protected ynamides with substituted 1,2-benzisoxazoles for the synthesis of E-benzo[e][1,3]oxazine derivatives. The transformation involves the addition of benzisoxazole to the gold-activated ynamide, ring expansion of the benzisoxazole fragment to provide an alpha-imino vinylic gold intermediate, and 1,2-migration of the sulfonamide motif to the masked carbene center to deliver the respective ring-expanded benzo[e][1,3]oxazine of predominant E configuration. A trapping experiment justifies the participation of the alpha-imino masked gold carbene. DFT computations also support the hypothesized mechanism and rationalize the product stereoselectivity.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics