123-76-2, Name is 4-Oxopentanoic acid, molecular formula is C5H8O3, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Liu, KH, once mentioned the new application about 123-76-2, Recommanded Product: 4-Oxopentanoic acid.
High-performance liquid chromatographic assay of zonisamide (1,2-benzisoxazole-3-methanesulfonamide) in human plasma using a solid-phase extraction technique
A selective and sensitive liquid chromatographic method was developed for the determination of zonisamide in small volumes of plasma. Zonisamide and the internal standard methyl 4-hydroxybenzoate were extracted from 0.2 mL. of plasma with solid-phase extraction columns and eluted with methanol. Analysis of the extracts was performed on a Symmetry C-18 column with ultra-violet spectrophotometric detection. The calibration curve was linear over the concentration range of 0.05-5 mug mL(-1) in plasma. Recoveries were reasonable for routine analyses; the limit of quantification was 0.05 mug mL(-1) with a signal-to-noise ratio of 5. This method could be useful for the pharmacokinetic study of zonisamide in a limited volume of human plasma and for therapeutic drug monitoring.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics