Category: 112-37-8

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The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia

D-Amino acid oxidase (DAO) has been established to be involved in the oxidation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the brain, and to be associated with the onset of schizophrenia. The effect of risperidone, a benzisoxazole derivative, atypical antischizophrenic drug, on the activity of human DAO was tested using an in-vitro oxygraph system and rat C6, stable C6 transformant cells overexpressing mouse DAO (designated as C6/DAO) and pig kidney epithelial cells (LLC-PK1). Risperidone has a hyperbolic mixed- type inhibition, designated as ‘partial uncompetitive inhibition effect’, with K-i value of 41 mu M on human DAO. Risperidone exhibited a protective effect from D-amino acid induced cell death in both C6/DAO and LLC-PK1 cells with 10% increase in viability. These data indicate the involvement of DAO activity in D-serine metabolism and also suggest a new mechanism of action to risperidone as antischizophrenic drug.

If you are hungry for even more, make sure to check my other article about 112-37-8, Safety of Undecanoic acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 112-37-8, Name is Undecanoic acid, molecular formula is , belongs to Benzisoxazole compound. In a document, author is Rangappa, KS, Computed Properties of C11H22O2.

New cholinesterase inhibitors: synthesis and structureactivity relationship studies of 1,2-benzisoxazole series and novel imidazolyl-d(2)-isoxazolines

The syntheses of a series of 3-(4-substituted-1-piperidinyl)-6-halo-1,2-benzisoxazole hydrochlorides (5a-b, 6a-b and 7a-b) and 3-(2-butyl-4-chloro-1H-imidazolyl)-substituted-d(2)-isoxazolines (10c-i)by novel methods are described. The inhibitory activity of acety1cholinesterase (AChE) for the newly synthesized compounds against targets from different species, such as pure electric eel AChE, human serum AChE and rat brain AChE, was studied using Ellman et al.’s method. The benzisoxazole heterocycle was found to be an appropriate bioisosteric replacement for the benzyl functionality present in the N-benzylpiperidine class of inhibitors. Structure-activity relationships were studied by comparing the basicities of the different substituted heterocyclic ring systems at the C-3 position of the 1,2-benzisoxazoles derivatives. Maximum cholinesterase enzyme inhibition was revealed when there was a 6-fluoro substituent on the 1,2-benzisoxazole ring. The 1-morpholine hydrochloride substituent appeared less significant, although in most cases 5a, 6a and 10c evoked maximum potency compared with the existing drug neostigmine. The most potent cholinesterase compound was found to be 1-[2-[6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole}ethyl]piperidine monohydrochloride (5a) by in vitro studies. Copyright (c) 2005 John Wiley & Sons, Ltd.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 112-37-8, in my other articles. Computed Properties of C11H22O2.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics