Category: 127-17-3

Application of 127-17-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 127-17-3, Name is 2-Oxopropanoic acid, SMILES is CC(C(O)=O)=O, belongs to benzisoxazole compound. In a article, author is Aidene, Mohand, introduce new discover of the category.

Reactivity of 2,1-Benzisoxazole in Palladium-Catalyzed Direct Arylation with Aryl Bromides

The Pd-catalyzed direct arylation of 2,1-benzisoxazole with aryl bromides to access 3-arylbenzoisoxazoles proceeds in moderate-to-high yields with 1mol% Pd(OAc)(2) or 2mol% PdCl(C3H5)(dppb) (dppb=1,4-bis(diphenylphosphino)butane) as the catalysts and KOAc as an inexpensive base. A wide variety of (hetero)aryl bromides have been employed successfully. Moreover, arylations followed by benzisoxazole ring opening allowed the preparation of 2-aminobenzophenones in only two steps.

Application of 127-17-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 127-17-3 is helpful to your research.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

127-17-3, Name is 2-Oxopropanoic acid, molecular formula is C3H4O3, Category: Benzisoxazole, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Malik, Sachin, once mentioned the new application about 127-17-3.

Design and synthesis of (5-amino-1, 2, 4-triazin-6-yl)(2-(benzo[d] isoxazol-3-yl) pyrrolidin-1-yl)methanone derivatives as sodium channel blocker and anticonvulsant agents

A series of novel (5-amino-3-substituted-1, 2, 4-triazin-6-yl) (2-(6-halo-substituted benzo[d]isoxazol-3-yl) pyrrolidin-1-yl) methanone 5a-5r was synthesized. Their anticonvulsant activities were evaluated by the maximal electroshock (MES) test and neurotoxicity was evaluated by the rotorod test. The MES test showed that (5-amino-3-phenyl-1, 2, 4-triazin-6-yl)(2-(6-fluorobenzo[d]isoxazol-3-yl) pyrrolidin-1-yl) methanone 5c was found to be the most potent compound with ED50 value of 6.20 mg/kg (oral/rat) and a protective index (PI = ED50/TD50) value of >48.38, which was much higher than the PI of the reference drug phenytoin. To explain the possible mechanism of action of selected derivatives 5b, 5c, 5i and 5o, their influence on sodium channel was evaluated in vitro.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 127-17-3 help many people in the next few years. Category: Benzisoxazole.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 127-17-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 127-17-3, Name is 2-Oxopropanoic acid, SMILES is CC(C(O)=O)=O, belongs to Benzisoxazole compound. In a article, author is Kozielewicz, Pawe, introduce new discover of the category.

Arene-fused 1,2-oxazole N-oxides and derivatives. The impact of the N-O dipole and substitution on their aromatic character and reactivity profile. Can it be a useful structure in synthesis? A theoretical insight

DFT calculations have shown that the N-O dipole of benzene- and naphthalene-fused 1,2-oxazole N-oxides causes a distortion of their sigma and pi frame, concentrated on the 1,2-oxazole ring, such that it increases its susceptibility to opening. The distortion forces the benzene ring into some diene geometry, thus, reducing pi delocalization over the bi- or tricyclic structure and ultimately their aromatic character. C-3 substitution has a marked influence mainly on the naphthalene-fused N-oxides. C-5 and particularly C-6 substitution, as the position of most extended interaction with the N-O dipole through the pi ring density, contribute to the distortion of the 1,2-oxazole geometry and thereby to the decrease of aromaticity of the structure. Bond uniformity (I (A)), average bond order (ABO) and Harmonic Oscillator Model of Aromaticity (HOMA) indices have been recruited to measure aromaticity changes. I (A) and ABO appear to be more credible to 1,2-benzoxazole N-oxides and 1,2-naphthoxazole N-oxides, respectively, while HOMA has been found equally reliable to both. Hardness and dipole moments follow similar trends. Energies, localization and separation of the four frontiers orbitals, i.e. HO, HO-1, and LU, LU+1, indicate a rather notable aromatic character of the N-oxides. Their reactivity profile, portrayed by descriptors such as Fukui and electro(nucleo)philicity Parr functions, shows good agreement with experimental outcomes towards electrophiles but succumbs to discrepancies towards nucleophiles due to the susceptibility of the hetero-ring to opening. The push-pull character of the N-O dipole and more importantly the extent of its double bonding direct site selectivity.

Related Products of 127-17-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 127-17-3.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of 127-17-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 127-17-3, Name is 2-Oxopropanoic acid, SMILES is CC(C(O)=O)=O, belongs to Benzisoxazole compound. In a article, author is Ward, Michael D., introduce new discover of the category.

Coordination Cages Based on Bis(pyrazolylpyridine) Ligands: Structures, Dynamic Behavior, Guest Binding, and Catalysis

CONSPECTUS: We describe here a family of coordination cages with interesting structural, guest-binding, and catalytic properties. Flexible bridging ligands containing two bidentate pyrazolylpyridine termini assemble with transition-metal dications to afford coordination cages containing a metal ion at each vertex, a bridging ligand spanning each edge, and a 2:3 metal:ligand ratio. This stoichiometry is expressed in structures ranging from M4L6 tetrahedra to M16L24 tetracapped truncated tetrahedra, which are stabilized by the formation of pi-stacked arrays between electron-rich and electron-poor ligand segments that form around the cage periphery. In some cases concentration- and/or temperature-dependent equilibria between multiple cage structures occur, arising from a balance between entropy, which favors the formation of a larger number of smaller assemblies, and enthalpy, which maximizes both interligand aromatic stacking and solvophobic effects in the larger assembles. The cages are hollow and can accommodate guests often anions or solvent molecules in the central cavity. For one cage family, M8L12 species with an approximately cubic structure and a ca. 400 angstrom(3) cavity, the guest binding properties have been studied extensively. This cage can accommodate a wide range of neutral organic guests, with binding in water being driven principally by the hydrophobic effect, which leads to binding constants of up to 10(8) W-1. The accumulation of a large amount of empirical data on guest binding in the M8L12 cage in water provided the basis for a predictive tool for in silico screening of potential guests using the molecular docking program GOLD; this methodology has allowed the identification of numerous new guests with accurately predicted binding constants and provides a transformative new approach to exploring the host/guest chemistry of cages. Binding of benzisoxazole inside the M8L12 cage results in substantial rate enhancements by a factor of up to 2 x 10(3) -of the Kemp elimination, in which benzisoxazole reacts to give 2-cyanophenolate. Catalysis arises because the 16+ cage cation accumulates anions around the surface by ion pairing, leading to a high effective concentration of hydroxide ions surrounding the guest even when the bulk pH is modest. Thus, the catalysis relies on the operation of two orthogonal interactions that bring the reaction partners together: hydrophobic guest binding in the cavity, which is lined with CH groups from the ligands, and ion pairing around the highly cationic cage surface. A consequence of this is that under some conditions the product of the cage catalyzed Kemp elimination (the 2-cyanophenolate anion) itself accumulates around the cage surface and deprotonates another benzisoxazole guest, perpetuating the reaction in an autocatalytic manner. Thus, different anions accumulating around the cage can act as partners for reaction with a cavity-bound guest, opening up the possibility that the M8L12 cage can act as a general catalyst for reactions of electrophilic guests with surface-bound anions.

Synthetic Route of 127-17-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 127-17-3.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 127-17-3, Name is 2-Oxopropanoic acid, molecular formula is , belongs to Benzisoxazole compound. In a document, author is Nunes, Claudio M., Quality Control of 2-Oxopropanoic acid.

Heavy-Atom Tunneling Through Crossing Potential Energy Surfaces: Cyclization of a Triplet 2-Formylarylnitrene to a Singlet 2,1-Benzisoxazole

Not long ago, the occurrence of quantum mechanical tunneling (QMT) chemistry involving atoms heavier than hydrogen was considered unreasonable. Contributing to the shift of this paradigm, we present here the discovery of a new and distinct heavy-atom QMT reaction. Triplet syn-2-formyl-3-fluorophenylnitrene, generated in argon matrices by UV-irradiation of an azide precursor, was found to spontaneously cyclize to singlet 4-fluoro-2,1-benzisoxazole. Monitoring the transformation by IR spectroscopy, temperature-independent rate constants (k approximate to 1.4×10(-3) s(-1); half-life of approximate to 8 min) were measured from 10 to 20 K. Computational estimated rate constants are in fair agreement with experimental values, providing evidence for a mechanism involving heavy-atom QMT through crossing triplet to singlet potential energy surfaces. Moreover, the heavy-atom QMT takes place with considerable displacement of the oxygen atom, which establishes a new limit for the heavier atom involved in a QMT reaction in cryogenic matrices.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 127-17-3, in my other articles. Quality Control of 2-Oxopropanoic acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry is an experimental science, Safety of 2-Oxopropanoic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 127-17-3, Name is 2-Oxopropanoic acid, molecular formula is C3H4O3, belongs to Benzisoxazole compound. In a document, author is Marino, Jehan.

Iloperidone for the Treatment of Schizophrenia

OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety data of iloperidone for the treatment of schizophrenia. DATA SOURCES: Data were selected by searching Pre-MEDLINE, MEDLINE, and International Pharmaceutical Abstracts (1966 January 2010). Abstracts, scientific posters, and unpublished data provided by the manufacturer in the English language were also assessed. STUDY SELECTION AND DATA EXTRACTION: All published data including pharmacologic, pharmacokinetic, pharmacodynamic, and clinical studies related to iloperidone were considered for inclusion. Selected studies included randomized controlled trials, abstracts, and posters presented at national scientific meetings providing pertinent data. data synthesis: Iloperidone is a benzisoxazole phenylethanone with a higher affinity for serotonin-2a than dopamine-2 receptors. The recommended therapeutic total daily dose is 12-24 mg divided in 2 doses titrated over 1 week to avoid orthostasis. Acute, 6-week, randomized, placebo-controlled, and active-controlled studies demonstrated iloperidone’s efficacy in reducing psychotic symptoms according to changes in the total positive and negative symptom scale (PANSS-T) score from baseline. A long-term maintenance trial demonstrated similar efficacy with haloperidol in preventing time to relapse. Pharmacogenomic studies reported possible single nucleotide polymorphisms related to QT interval prolongation and efficacy with iloperidone. Common adverse effects included dizziness, dry mouth, and sustained orthostasis occurring more frequently with higher doses. Weight gain is possible at any dose. Additionally, studies showed that QTc interval prolongation may be dose related. The incidence of extrapyramidal symptoms appears to be low across all dosage ranges; however, akathisia may be more frequent with higher doses. CONCLUSIONS: Iloperidone demonstrated efficacy in acute exacerbations and long-term maintenance in adults with schizophrenia. Caution may be warranted in elderly patients and patients with cardiac disease, due to orthostasis. Further studies regarding pharmacogenomic testing related to the drug’s efficacy and tolerability are needed to justify its routine use in practice.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 127-17-3. Safety of 2-Oxopropanoic acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Reference of 127-17-3, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 127-17-3, Name is 2-Oxopropanoic acid, SMILES is CC(C(O)=O)=O, belongs to Benzisoxazole compound. In a article, author is Liu, KH, introduce new discover of the category.

High-performance liquid chromatographic assay of zonisamide (1,2-benzisoxazole-3-methanesulfonamide) in human plasma using a solid-phase extraction technique

A selective and sensitive liquid chromatographic method was developed for the determination of zonisamide in small volumes of plasma. Zonisamide and the internal standard methyl 4-hydroxybenzoate were extracted from 0.2 mL. of plasma with solid-phase extraction columns and eluted with methanol. Analysis of the extracts was performed on a Symmetry C-18 column with ultra-violet spectrophotometric detection. The calibration curve was linear over the concentration range of 0.05-5 mug mL(-1) in plasma. Recoveries were reasonable for routine analyses; the limit of quantification was 0.05 mug mL(-1) with a signal-to-noise ratio of 5. This method could be useful for the pharmacokinetic study of zonisamide in a limited volume of human plasma and for therapeutic drug monitoring.

Reference of 127-17-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 127-17-3 is helpful to your research.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 127-17-3, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 127-17-3, Name is 2-Oxopropanoic acid, SMILES is CC(C(O)=O)=O, belongs to Benzisoxazole compound. In a article, author is Dzhons, Daria Yu., introduce new discover of the category.

Synthesis of 2,1-benzisoxazole-3(1H)-ones by base-mediated photochemical N-O bond-forming cyclization of 2-azidobenzoic acids

The base-mediated photochemical cyclization of 2-azidobenzoic acids with the formation of 2,1-benzisoxazole-3(1H)-ones is reported. The optimization and scope of this cyclization reaction is discussed. It is shown that an essential step of the ring closure of 2-azidobenzoic acids is the formation and photolysis of 2-azidobenzoate anions.

Related Products of 127-17-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 127-17-3.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 127-17-3, Name is 2-Oxopropanoic acid, molecular formula is C3H4O3, belongs to Benzisoxazole compound. In a document, author is Nakasa, H, introduce the new discover, Quality Control of 2-Oxopropanoic acid.

Formation of 2-sulphamoylacetylphenol from zonisamide under aerobic conditions in rat liver microsomes

1. The antiepileptic agent zonisamide, 1,2-benzisoxazole-3-methanesulphonamide, was metabolized reductively to 2-sulphamoyl-acetylphenol (SMAP) not only under anaerobic conditions but also under aerobic conditions in liver microsomes of rat pretreated with phenobarbital or dexamethasone. 2. NADPH was required for the formation of SMAP from zonisamide under aerobic conditions. In addition, the reductive metabolism of zonisamide under these conditions was substantially inhibited by carbon monoxide, ketoconazole, and cimetidine, known inhibitors of cytochrome P450. 3. The formation of SMAP under aerobic conditions in liver microsomes was increased by pretreatment of rat with triacetyloleandomycin (TAO) and was increased by the treatment of the microsomes with ferricyanide. 4. These results imply that zonisamide is metabolized reductively to SMAP by a cytochrome P450 belonging to the 3A subfamily under aerobic conditions as well as anaerobic conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 127-17-3. Quality Control of 2-Oxopropanoic acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of 127-17-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 127-17-3, Name is 2-Oxopropanoic acid, SMILES is CC(C(O)=O)=O, belongs to Benzisoxazole compound. In a article, author is NAKASA, H, introduce new discover of the category.

RAT-LIVER MICROSOMAL CYTOCHROME-P-450 RESPONSIBLE FOR REDUCTIVE METABOLISM OF ZONISAMIDE

The reductive metabolism of 1,2-benzisoxazole-3-methanesulfonamide (zonisamide) to 2-sulfamoylacetylphenol (SMAP) was observed in liver microsomes from female rats, as well as male rats, but the SMAP-producing activity in female rats was 4-fold lower than that found in male rats. In addition, the reductive metabolism of zonisamide in liver microsomes was induced by the treatment of male rats with phenobarbital. However, the SMAP-producing activity did not correlate positively with the amounts of P-450 2B1 and P-450 2C11 immunochemically determined. In contrast, the reductive metabolism of zonisamide was also found to be induced by the pretreatment of male rats with pregnenolone 16alpha-carbonitrile, triacetyloleandomycin, and dexamethasone. Furthermore, the SMAP-producing activity correlated highly with the amount of P-450 cross-reactive with antihuman P-450 3A4 antibody, suggesting that P-450 3A1/2 may function in the reductive metabolism of zonisamide. In addition, the P-450 PCNa (3A2) exhibited the SMAP-producing activity in a reconstituted system. The antihuman P-450 3A4 antibody inhibited markedly the formation of SMAP from zonisamide in male rat liver microsomes. These results indicate that cytochrome(s) P-450 belonging to P-450 3A subfamily may be predominantly responsible for the reductive metabolism of zonisamide in rat liver microsomes.

Synthetic Route of 127-17-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 127-17-3 is helpful to your research.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics