Category: 3326-71-4

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Electric Literature of C5H6N2O2.Goergen, Christina; Boden, Katharina; Reiss, Guido J.; Frank, Walter; Mueller, Thomas J. J. published the article 《One-pot activation-alkynylation-cyclization synthesis of 1,5-diacyl-5-hydroxypyrazolines in a consecutive three-component fashion》 about this compound( cas:3326-71-4 ) in Beilstein Journal of Organic Chemistry. Keywords: diacyl hydroxypyrazoline preparation; hetero aryl glyoxylic acid arylacetylene hydrazide activation alkynylation cyclization; C–C coupling; activation; alkynylation; copper; cyclization; multicomponent reactions. Let’s learn more about this compound (cas:3326-71-4).

A consecutive three-component activation-alkynylation-cyclization reaction of (hetero)aryl glyoxylic acids, oxalyl chloride, arylacetylenes, and hydrazides efficiently forms 1,5-diacyl-5-hydroxypyrazolines in moderate to good yields. The structures were unambiguously corroborated by comprehensive NMR spectroscopy and X-ray structure analyses of selected derivatives

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

SDS of cas: 3326-71-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Solid-phase synthesis of hybrid 2,5-diketopiperazines using acylhydrazide, carbazate, semicarbazide, amino acid, and primary amine submonomers. Author is Rahim, Abdur; Sahariah, Biswajit; Baruah, Kalpita; Deka, Jugal Kishore Rai; Sarma, Bani Kanta.

46We report the solid-phase synthesis of N,N’-di(acylamino)-2,5-diketopiperazine, an acylhydrazide-based conformationally rigid 2,5-DKP scaffold having exocyclic N-N bonds. We also show that different combinations of acylhydrazides, carbazates, semicarbazides, amino acids, and primary amines can be used to synthesize a highly diverse collection of hybrid DKP mols. via the solid-phase submonomer synthesis route. Finally, we show incorporation of a Me substituent in one of the carbon atoms of the DKP ring to generate chiral daa- and hybrid-DKPs without compromising the synthetic efficiency.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.SDS of cas: 39901-94-5. The article 《Systematic approach of chromone skeleton for detecting Mg2+, ion: Applications for sustainable cytotoxicity and cell imaging possibilities》 in relation to this compound, is published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. Let’s take a look at the latest research on this compound (cas:3326-71-4).

The systematic studies of chromone appended novel chemosensors, favored to Mg2+ ion detection, these were analyzed and characterized by different spectroscopic techniques such as NMR, mass spectroscopy, FTIR and optical techniques. The binding demeanor of the ligands was executed with the library of metal ions and shown the good coordination with Mg2+ ion to the ligand′s cavity. Both ligands demonstrated good binding behavior with Mg2+ ion. The ligands represented 1: 1 stoichiometry with Mg2+ ions through Job′s plot. The low limit of detection of Mg2+ ion was determined as 2.56 × 10-6 and 1.28 × 10-6 for La and Lb, resp. No interference was occurred in Inference study by foreign metal ions that supported the specific detection of Mg2+ ion among the other metal ions. Further, the cytotoxicity assay test of these chromone appended ligands revealed that both ligands and their resp. compound with Mg2+ ion shown negligible toxicity with HeLa cancer cell line. Further, due to the fluorescence properties of the ligands, with or without Mg2+ ion was successfully tested in bioimaging experiment of HeLa cancer cell lines and found that ligands with Mg2+ ions represented good imaging with HeLa cancer cell.

After consulting a lot of data, we found that this compound(3326-71-4)Recommanded Product: 2-Furoic hydrazide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about Catalyst-free, aza-Michael polymerization of hydrazides: polymerizability, kinetics, and mechanistic origin of an α-effect, the main research direction is aza Michael polymerization divinylsulfone diacrylate hydrazide alpha effect.SDS of cas: 3326-71-4.

Despite the powerful nature of the aza-Michael reaction for generating C-N linkages and bioactive moieties, the bis-Michael addition of 1° amines remains ineffective for the synthesis of functional, step-growth polymers due to the drastic reduction in reactivity of the resulting 2° amine mono-addition adduct. In this study, a wide range of com. hydrazides are shown to effectively undergo the bis-Michael reaction with divinyl sulfone (DVS) and 1,6-hexanediol diacrylate (HDA) under catalyst-free, thermal conditions to afford moderate to high mol. weight polymers with Mn = 3.8-34.5 kg mol-1. The hydrazide-Michael reactions exhibit two distinctive, conversion-dependent kinetic regimes that are 2nd-order overall, in contrast to the 3rd-order nature of amines previously reported. The mono-addition rate constant was found to be 37-fold greater than that of the bis-addition at 80°C for the reaction between benzhydrazide and DVS. A significant majority (12 of 15) of the hydrazide derivatives used here show excellent bis-Michael reactivity and achieve >97% conversions after 5 days. This behavior is consistent with calculations that show minimal variance of electron d. on the N-nucleophile among the derivatives studied. Reactivity differences between hydrazides and hexylamine are also explored. Overall, the difference in reactivity between hydrazides and amines is attributed to the adjacent nitrogen atom in hydrazides that acts as an efficient hydrogen-bond donor that facilitates intramol. proton-transfer following the formation of the zwitterion intermediate. This effect not only activates the Michael acceptor but also coordinates with addnl. Michael acceptors to form an intermol. reactant complex.

After consulting a lot of data, we found that this compound(3326-71-4)SDS of cas: 3326-71-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3326-71-4, is researched, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2Journal, Article, Luminescence called A highly selective aggregation-induced emission fluorogen for sensitive detection of Al3+ in living cells, Author is Xie, Ya; Li, Xueming; Yan, Liqiang; Li, Jianping, the main research direction is A549 cell aggregation induced emission fluorogen aluminum; AIE; Al3+; Schiff’s base; coumarin; fluorescence probe.Computed Properties of C5H6N2O2.

A Schiff’s base derivative was synthesized using a condensation reaction between 8-formyl-7-hydroxy-4-methylcoumarin and furan-2-carbohydrazide that produced marked aggregation-induced emission and had excellent ability to specifically recognize aluminum ions (Al3+). This compound displayed faint fluorescence in the benign solvent DMF, and exhibited obvious green fluorescence following addition of specific amounts of water. Moreover, it exhibited strong blue fluorescence after combination with Al3+ even in the presence of other interfering ions. These exptl. results demonstrated that this derivative could be used as a fluorescence probe for Al3+. The advantages, including significant fluorescence change, high selectivity and sensitivity, and fast response, meant that this probe could be used both to detect Al3+ in water samples and for fluorescence imaging in living cells.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 3326-71-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Nucleophilic catalysis of p-substituted aniline derivatives in acylhydrazone formation and exchange. Author is Canal-Martin, Andrea; Navo, Claudio D.; Saez, Elena; Molero, Dolores; Jimenez-Oses, Gonzalo; Perez-Fernandez, Ruth.

A mechanistic study and superior performance of electron-rich p-substituted aniline derivatives as catalysts for efficient hydrazone formation and exchange in both protic and aprotic solvents was reported. Rigorous kinetic analyses demonstrate that imine formation with 3-hydroxy-4-nitrobenzaldehyde and aniline derivatives proceeds with unprecedented third-order kinetics in which the aldehyde consistently shows a partial order of two. Computational investigations provide insights into the mechanisms of these transformations.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 2-Furoic hydrazide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Crystal structure of N′-[4-(dimethylamino)benzylidene]furan-2-carbohydrazide monohydrate. Author is Sylla-Gueye, Rokhaya; Thiam, Ibrahima Elhadji; Orton, James; Coles, Simon; Gaye, Mohamed.

The condensation of 2-furoic hydrazide and 4-dimethyl aminobenzaldehyde in ethanol yielded a yellow solid formulated as the title compound, C14H15N3O2·H2O. The crystal packing is stabilized by intermol. O(water)-H···O,N(carbohydrazide) and N-H···O(water) hydrogen bonds, which form a two-dimensional network along the bc plane. Addnl. C-H···O interactions link the mols. into a three-dimensional network. The dihedral angle between the mean planes of the benzene and the furan ring is 34.47 (6)°. The carbohydrazide moiety, i.e., the C=N-N-C=O fragment and the benzene ring are almost coplanar, with an angle of 6.75 (9)° between their mean planes.

After consulting a lot of data, we found that this compound(3326-71-4)Recommanded Product: 2-Furoic hydrazide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A novel turn on fluorescent probe for the determination of Al3+ and Zn2+ ions and its cells applications.Application In Synthesis of 2-Furoic hydrazide.

Early detection of probes is very important for limiting toxic effects of various transition metal ions for example aluminum and zinc. Monitoring of these metal ions can be challenging via conventional methods since they are high cost instrumentations, time consuming and so on. The authors report facile preparation of a fluorescence probe containing biphenyl groups that effectively selective and superb sensitivity towards aluminum(III) and zinc(II) in neutral solutions without interference from each other and other ions. In neutral pH value, the probe FOB displayed the OFF-ON fluorescence enhancement at 464 nm and 512 nm toward aluminum(III) and zinc(II), resp. The detection limit values of FOB for Al3+ and Zn2+ in neutral solutions were 1.27 and 1.02 nM, resp. and these values were significantly lower than permitted Al3+ and Zn2+ concentrations in drinking water determined by the World Health Organization (WHO) and European Water Quality. Also, fabricated cyano-biphenyl based probe is effective for sensing for aluminum(III) and zinc(II) in living human colon cancer cells even when employed at low concentrations (1.0μM). Overall, this work allows the authors to obtain a great potential to be applied to detect Al3+ and Zn2+.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Application In Synthesis of 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine. The article 《Tin-Mediated One-pot Preparation of β-Trifluoromethyl-β-acylhydrazonyl Carbonyl Compounds》 in relation to this compound, is published in Asian Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:3326-71-4).

A concise and efficient protocol for the preparation of β-trifluoromethyl-β-acylhydrazonyl carbonyl compounds was developed from multicomponent one-pot reactions of trifluoroacetaldehyde Me hemiacetal, acylhydrazines and 2-bromocarbonyl compounds in the presence of tin powder. The reactions can be carried out under mild reaction conditions to give the products in good to excellent yields.

Although many compounds look similar to this compound(3326-71-4)Product Details of 3326-71-4, numerous studies have shown that this compound(SMILES:O=C(C1=CC=CO1)NN), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Love, Dillon; Kim, Kangmin; Domaille, Dylan W.; Williams, Olivia; Stansbury, Jeffrey; Musgrave, Charles; Bowman, Christopher published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).COA of Formula: C5H6N2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

Despite the powerful nature of the aza-Michael reaction for generating C-N linkages and bioactive moieties, the bis-Michael addition of 1° amines remains ineffective for the synthesis of functional, step-growth polymers due to the drastic reduction in reactivity of the resulting 2° amine mono-addition adduct. In this study, a wide range of com. hydrazides are shown to effectively undergo the bis-Michael reaction with divinyl sulfone (DVS) and 1,6-hexanediol diacrylate (HDA) under catalyst-free, thermal conditions to afford moderate to high mol. weight polymers with Mn = 3.8-34.5 kg mol-1. The hydrazide-Michael reactions exhibit two distinctive, conversion-dependent kinetic regimes that are 2nd-order overall, in contrast to the 3rd-order nature of amines previously reported. The mono-addition rate constant was found to be 37-fold greater than that of the bis-addition at 80°C for the reaction between benzhydrazide and DVS. A significant majority (12 of 15) of the hydrazide derivatives used here show excellent bis-Michael reactivity and achieve >97% conversions after 5 days. This behavior is consistent with calculations that show minimal variance of electron d. on the N-nucleophile among the derivatives studied. Reactivity differences between hydrazides and hexylamine are also explored. Overall, the difference in reactivity between hydrazides and amines is attributed to the adjacent nitrogen atom in hydrazides that acts as an efficient hydrogen-bond donor that facilitates intramol. proton-transfer following the formation of the zwitterion intermediate. This effect not only activates the Michael acceptor but also coordinates with addnl. Michael acceptors to form an intermol. reactant complex.

Although many compounds look similar to this compound(3326-71-4)COA of Formula: C5H6N2O2, numerous studies have shown that this compound(SMILES:O=C(C1=CC=CO1)NN), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics