Category: 3326-71-4

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Inorganic Chemistry called Water-Soluble Dioxidovanadium(V) Complexes of Aroylhydrazones: DNA/BSA Interactions, Hydrophobicity, and Cell-Selective Anticancer Potential, Author is Sahu, Gurunath; Banerjee, Atanu; Samanta, Rajib; Mohanty, Monalisa; Lima, Sudhir; Tiekink, Edward R. T.; Dinda, Rupam, which mentions a compound: 3326-71-4, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2, Application In Synthesis of 2-Furoic hydrazide.

Five new anionic aqueous dioxidovanadium(V) complexes, [{VO2L1,2}A(H2O)n]α (1-5), with the aroylhydrazone ligands pyridine-4-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L1) and furan-2-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L2) incorporating different alkali metals (A = Na+, K+, Cs+) as countercation were synthesized and characterized by various physicochem. techniques. The solution-phase stabilities of 1-5 were determined by time-dependent NMR and UV-visible, and also the octanol/water partition coefficients were obtained by spectroscopic techniques. X-ray crystallog. of 2-4 confirmed the presence of vanadium(V) centers coordinated by two cis-oxido-O atoms and the O, N, and O atoms of a dianionic tridentate ligand. To evaluate the biol. behavior, all complexes were screened for their DNA/protein binding propensity through spectroscopic experiments Finally, a cytotoxicity study of 1-5 was performed against colon (HT-29), breast (MCF-7), and cervical (HeLa) cancer cell lines and a noncancerous NIH-3T3 cell line. The cytotoxicity was cell-selective, being more active against HT-29 than against other cells. In addition, the role of hydrophobicity in the cytotoxicity was explained in that an optimal hydrophobicity is essential for high cytotoxicity. Moreover, the results of wound-healing assays indicated antimigration in case of HT-29 cells. Remarkably, 1 with an IC50 value of 5.42 ± 0.15μM showed greater activity in comparison to cisplatin against the HT-29 cell line.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Electrosynthesis of 2-(1,3,4-Oxadiazol-2-yl)aniline Derivatives with Isatins as Amino-Attached C1 Sources, the main research direction is oxadiazolyl aniline electrosynthesis intramol decarboxylative coupling isatin hydrazine.Recommanded Product: 2-Furoic hydrazide.

An intramol. decarboxylative coupling reaction for the construction of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives was developed from readily available isatins and hydrazides by virtue of electrochem. In this reaction, isatins were employed as amino-attached C1 sources, providing a variety of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives with moderate to good yields.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Electric Literature of C5H6N2O2.Sylla-Gueye, Rokhaya; Thiam, Ibrahima Elhadji; Orton, James; Coles, Simon; Gaye, Mohamed published the article 《Crystal structure of N′-[4-(dimethylamino)benzylidene]furan-2-carbohydrazide monohydrate》 about this compound( cas:3326-71-4 ) in Acta Crystallographica, Section E: Crystallographic Communications. Keywords: furoic hydrazide dimethyl aminobenzaldehyde crystal structure; crystal structure; furoic acid; hydrazide; hydrazone. Let’s learn more about this compound (cas:3326-71-4).

The condensation of 2-furoic hydrazide and 4-dimethyl aminobenzaldehyde in ethanol yielded a yellow solid formulated as the title compound, C14H15N3O2·H2O. The crystal packing is stabilized by intermol. O(water)-H···O,N(carbohydrazide) and N-H···O(water) hydrogen bonds, which form a two-dimensional network along the bc plane. Addnl. C-H···O interactions link the mols. into a three-dimensional network. The dihedral angle between the mean planes of the benzene and the furan ring is 34.47 (6)°. The carbohydrazide moiety, i.e., the C=N-N-C=O fragment and the benzene ring are almost coplanar, with an angle of 6.75 (9)° between their mean planes.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Yu, Xiang; Zhao, You-Fang; Huang, Guo-Juan; Chen, Ya-Fang published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).Electric Literature of C5H6N2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

Twelve novel 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives I [R = n-Bu, 2-thienyl, Ph, etc.] were synthesized via iodine-mediated oxidative cyclization and confirmed by 1H NMR, 13C NMR and HRMS. The synthesized derivatives I were tested against in-vitro acetylcholinesterase inhibitory activity and results showed that compounds I [R = 4-ClC6H4, 4-BrC6H4] exhibited moderate inhibitory activities with 69.19% and 65.06%, resp. The preliminary structure-activity relationships revealed that introduction of halogen atom on the para-position of Ph of compounds I could enhance their activities. Mol. docking study suggested that compound I [R = ClC6H4] possessed an optimal docking pose with interactions inside AChE.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3326-71-4, is researched, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2Journal, Article, Beilstein Journal of Organic Chemistry called One-pot activation-alkynylation-cyclization synthesis of 1,5-diacyl-5-hydroxypyrazolines in a consecutive three-component fashion, Author is Goergen, Christina; Boden, Katharina; Reiss, Guido J.; Frank, Walter; Mueller, Thomas J. J., the main research direction is diacyl hydroxypyrazoline preparation; hetero aryl glyoxylic acid arylacetylene hydrazide activation alkynylation cyclization; C–C coupling; activation; alkynylation; copper; cyclization; multicomponent reactions.Name: 2-Furoic hydrazide.

A consecutive three-component activation-alkynylation-cyclization reaction of (hetero)aryl glyoxylic acids, oxalyl chloride, arylacetylenes, and hydrazides efficiently forms 1,5-diacyl-5-hydroxypyrazolines in moderate to good yields. The structures were unambiguously corroborated by comprehensive NMR spectroscopy and X-ray structure analyses of selected derivatives

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3326-71-4, is researched, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2Journal, Journal of Molecular Structure called A new fluorescent chemosensor for Al(III) detection with highly selective in aqueous solution and solid test paper, Author is Xiu, Deping; Shi, Junjie; Deng, Miaoran; Song, Huihua; Hao, Zhiqiang; Feng, Qi; Yu, Haitao, the main research direction is fluorescent chemosensor Al detection test paper.Category: benzisoxazole.

A new fluorescent chemosensor (I) based on salicylaldehyde hydrazide was facilely synthesized through one-step reaction, which exhibited turn-on fluorescent response to Al(III) with 18-fold fluorescence enhancement in aqueous solution at pH 5.5. The binding stoichiometry of 1 toward Al(III) was in 1:1. High selectivity and sensitivity to Al(III) were achieved, which featured a detection limit of 67 nmol L-1 and a linear rang of 1-10 μmol L-1. More importantly, the sensing process could be also performed on solid test paper. After the addition of Al(III), a significant emission color change from yellow to cyan was observed by naked eye due to the intrinsic aggregation-induced emission (AIE) characteristic of 1.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Rodrigues, Daniel A.; Guerra, Fabiana S.; Sagrillo, Fernanda S.; Pinheiro, Pedro de Sena M.; Alves, Marina A.; Thota, Sreekanth; Chaves, Lorrane S.; Sant’Anna, Carlos M. R.; Fernandes, Patricia D.; Fraga, Carlos A. M. published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).Computed Properties of C5H6N2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacol. profile, and mol. modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kα dual inhibitors. The surprising selectivity for PI3Kα may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kα show potential for the treatment of cancer.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics