There is still a lot of research devoted to this compound(SMILES:O=C(C1OCCC1)OC)Application In Synthesis of Methyl tetrahydrofuran-2-carboxylate, and with the development of science, more effects of this compound(37443-42-8) can be discovered.
Application In Synthesis of Methyl tetrahydrofuran-2-carboxylate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about The enzymatic resolution of 1-(4-chlorophenyl)ethylamine by Novozym 435 to prepare a novel triazolopyrimidine herbicide.
The kinetic resolution of (R,S)-1-(4-chlorophenyl)ethylamine was accomplished using a com. lipase from Candida antarctica (Novozym 435). The performance of this lipase was investigated for the enantioselective amidation of (R,S)-1-(4-chlorophenyl)ethylamine, leaving the target product (S)-1-(4-chlorophenyl)ethylamine in its unreacted form. The effects of various types of solvents and an acyl donor, the molar ratio of the substrate to the acyl donor, and the reaction temperature were studied. The optimum reaction conditions were found to result in amidation with Me 2-tetrahydrofuroate at 40°C in Me tert-Bu ether, with a substrate/acyl donor molar ratio of 1:2.4. The conversion rate of (R,S)-1-(4-chlorophenyl)ethylamine was 52%, with an enantiomeric excess of 99% towards the unreacted substrate in a reaction time of 22 h. Finally, using optically pure (S)-1-(4-chlorophenyl)ethylamine as the raw material, the chem. synthesis of (S)-N-(1-(4-chlorphenyl)ethyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)acetamide, a novel triazolopyrimidine herbicide, was achieved, and the total yield and purity were 83.5% and 95.3%, resp.
There is still a lot of research devoted to this compound(SMILES:O=C(C1OCCC1)OC)Application In Synthesis of Methyl tetrahydrofuran-2-carboxylate, and with the development of science, more effects of this compound(37443-42-8) can be discovered.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics