Category: 37443-42-8

SDS of cas: 37443-42-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Synthesis and Anticancer Activity of Structure Simplified Naturally Inspired Dimeric Chromenone Derivatives. Author is Ali, Rameez; Guan, Yong; Leveille, Alexandria N.; Vaughn, Elizabeth; Parelkar, Sangram; Thompson, Paul R.; Mattson, Anita E..

Select dimeric chromenones exhibit low micromolar cytotoxicity toward lymphoma and leukemia cell lines, L5178Y and HL60, resp. The bioactive dimeric chromenones were identified from a focused library of structurally simplified derivatives of naturally occurring dimeric chromenones and tetrahydroxanthones that was prepared as part of this study. The simple dimeric chromenone scaffolds contain no stereogenic centers, are easily synthesized, and may be utilized as lead compounds in cancer research and drug discovery.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Reactions of furan compounds. IV. High-temperature decomposition of the vapors of tetrahydrofuronitrile and Me tetrahydrofuroate to give 2,3-dihydrofuran and cyclopropanealdehyde》. Authors are Wilson, Christopher L..The article about the compound:Methyl tetrahydrofuran-2-carboxylatecas:37443-42-8,SMILESS:O=C(C1OCCC1)OC).Safety of Methyl tetrahydrofuran-2-carboxylate. Through the article, more information about this compound (cas:37443-42-8) is conveyed.

Tetrahydrofuramide (I) is not dehydrated by COCl2 at high temperatures At 360-400° over silica gel, I gives a mixture of tetrahydrofuronitrile (II) and 2,3-dihydrofuran (III), together with some HCN; the yield of II at 290° was 74%, at 310° 55%, and at 330° 40% (yields are based on consumption, see Part III); over Na phosphate (pumice impregnated with 120 g. NaH2PO4 and 15 cc. H3PO4 in 85 cc. H2O and dried by heating slowly to 300°) at 400° the yield of II was 90%, consumption of I 50-85%. With N as carrier gas (2 l./hr.), 70% of II was recovered when passed over earthenware rings at 450°; 10% was impure III. Silica gel at 500° gives 20% of tetrahydrofuran (IV)-III mixture (48% of III), 10% of unchanged II and 10% of a compound (V), which may be CH2.CH2.C:CHCN, b. 130-40°. Na phosphate at 500° gives HCN, only a little III + IV and mainly cyclopropanecarboxaldehyde (VI), b14 42-4°; 2,4-dinitrophenylhydrazone, orange-red, m. 173-5°; p-nitrophenylhydrazone, golden-yellow, m. 129-32°; dimedon derivative, m. 160-2°. NH4 tetrahydrofuroate (aqueous solution containing an excess of NH3) over earthenware rings gives an equimol. mixture of the free acid and I; over silica gel at 500-600° V and II were formed; over Na phosphate, the temperature and carrier gas (N, CO2) appeared to have little influence on the results; between 450-550° there resulted 20-30% of a product b. 45-90° containing MeOH, III, and VI; over silica gel at 375°, the products were III and PrCHO (2,4-dinitrophenylhydrazone, orange-brown, m. 120-5°); at 400°, the ester gives 30% of a liquid containing some III and VI. VI was prepared in about 20% yield from Cl(CH2)3CN and SnCl2 in ether (saturated with HCl).

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Benzisoxazole – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Reaction of methyl tetrahydropyromucate with aniline. XXXI》. Authors are Yur’ev, Yu. K.; Vendel’shtein, E. G..The article about the compound:Methyl tetrahydrofuran-2-carboxylatecas:37443-42-8,SMILESS:O=C(C1OCCC1)OC).Formula: C6H10O3. Through the article, more information about this compound (cas:37443-42-8) is conveyed.

Passage of Me 2-furoate in a H atm. over Pd-asbestos at 160° gave 78% Me tetrahydro-2-furoate, b736 179.5-80.5°, n20D 1.4371, d204 1.1080. This (10 g.) and 27 g. PhNH2 passed in a N atm. over Al2O3 at 360° gave CO2, 14 g. PhNH2, and 1.5 g. 1-phenylpyrrolidine, b4 104-5°, n20D 1.5840, d204 1.0164; picrate, m. 116°. Passage of the ester at 360° over Al2O3 in a N atm. gave CO2, propene, and MeOH. Hydrolysis of the ester with 2 N NaOH 4 hrs. at reflux gave 76% free acid, a sirupy microcrystalline mass; this heated to 270-80° begins to lose CO2, which occurs freely at 300-5°, yielding furanidine, b755 65°, n20D 1.4088, d204 0.8899.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Application of 37443-42-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about A Powerful Chiral Phosphoric Acid Catalyst for Enantioselective Mukaiyama-Mannich Reactions. Author is Zhou, Fengtao; Yamamoto, Hisashi.

A new BINOL-derived chiral phosphoric acid bearing 2,4,6-trimethyl-3,5-dinitrophenyl substituents at the 3,3′-positions was developed. The utility of this chiral phosphoric acid is demonstrated by a highly enantioselective (ee up to >99 %) and diastereoselective (syn/anti up to >99:1) asym. Mukaiyama-Mannich reaction of imines with a wide range of ketene silyl acetals. Moreover, this method was successfully applied to the construction of vicinal tertiary and quaternary stereogenic centers with excellent diastereo- and enantioselectivity. Significantly, BINOL-derived N-triflyl phosphoramide constitutes a complementary catalyst system that allows the title reaction to be applied to more challenging imines without an N-(2-hydroxyphenyl) moiety.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Safety of Methyl tetrahydrofuran-2-carboxylate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Synthesis of mono-acylation piperazine compounds.

1-(2-Furoyl)piperazine (90.6%) and 1-(terahydro-2-furoyl)piperazine were synthesized by the esterification of 2-furoic acid and 2-tetrahydrofuroic acid with methanol, and then amidation with piperazine, resp. The structures were characterized by 1H NMR and IR.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl tetrahydrofuran-2-carboxylate(SMILESS: O=C(C1OCCC1)OC,cas:37443-42-8) is researched.Related Products of 415918-91-1. The article 《Chlorination of tetrahydrofuran-2-carboxylic acid esters》 in relation to this compound, is published in Khimiya Geterotsiklicheskikh Soedinenii. Let’s take a look at the latest research on this compound (cas:37443-42-8).

Photochem. chlorination of Me tetrahydro-2-furancarboxylate in CCl4 at -15 to -20° gave the chlorofurancarboxylate I and small amounts of the dihydrofuran II (8%) and Me 2-furancarboxylate (2%). Et tetrahydro-2-furancarboxylate was similarly chlorinated. The by-products were formed by dehydrochlorination of intermediate x-chlorination products.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Electric Literature of C6H10O3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Structural effects on rates and equilibriums. XVI. Effect of adjacent unshared electron pairs on ease of carbanion formation. Author is Hine, Jack; Dalsin, Philip D..

The kinetics of NaOMe catalyzed D exchange of Me cyclopentanecarboxylate, two of its oxa derivatives and their acyclic analogs were studied in MeOD solution At 35° methyl cyclopentanecarboxylate exchanged 13 times as fast as Me α-ethylbutyrate, Me tetrahydro-2-furancarboxylate exchanged four times as fast as Me α-methoxybutyrate, and Me 1,3-dioxolane-2-carboxylate exchanged half as fast as Me dimethoxyacetate. From these results it was concluded that rates of carbanion formation may be decreased by repulsions between the unshared electron pairs of the carbanionic C atom and those of O atoms attached directly to it. Such repulsions may be minimized by appropriate rotation around the C-O bond in acyclic compounds but not as easily in cyclic compounds This electron repulsion effect operates in addition to the electronegativity effect, by which rates of formation of sp2-hybridized carbanions are slowed by highly electroneg. atoms attached directly to the site of carbanion formation. This interpretation of the results is analogous to that required to explain to explain recent observations on rates of pyramidal inversions at N and P.

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Benzisoxazole – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Bulky Diarylammonium Arenesulfonates as Selective Esterification Catalysts, published in 2005-03-30, which mentions a compound: 37443-42-8, Name is Methyl tetrahydrofuran-2-carboxylate, Molecular C6H10O3, Quality Control of Methyl tetrahydrofuran-2-carboxylate.

More environmentally benign alternatives to current chem. processes, especially large-scale, fundamental reactions such as ester condensations, are highly desirable for many reactions. Bulky diarylammonium pentafluorobenzenesulfonates and tosylates serve as extremely active dehydration catalysts for the ester condensation reaction of carboxylic acids with equimolar amounts of sterically demanding alcs. and acid-sensitive alcs. Typically, the esterification reaction is performed in heptane by heating at 80 °C in the presence of 1 mol % of the catalyst without removing water. Esterification with primary alcs. proceeds without solvents even at room temperature Furthermore, 4-(N-mesitylamino)polystyrene resin-bound pentafluorobenzenesulfonate can be recycled more than 10 times without activity loss.

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Safety of Methyl tetrahydrofuran-2-carboxylate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about A scalable chemoenzymic preparation of (R)-tetrahydrofuran-2-carboxylic acid. Author is Fujima, Yoshito; Hirayama, Yoshihiro; Ikunaka, Masaya; Nishimoto, Yukifumi.

To develop a practical scalable approach to (R)-tetrahydrofuran-2-carboxylic acid (I), a chiral building block for furopenem, enantioselective hydrolysis of its esters is explored: When Et (±)-tetrahydrofuran-2-carboxylate (II, 2 M, 288 g/L) is digested by an Aspergillus melleus protease {0.2% (w/v)} in a 1.5 M potassium phosphate buffer (pH 8) for 20 h, enantioselective hydrolysis proceeds with E = 60 to give I in 94.4% ee. On separation from the leftover antipodal (S)-II by partition, I is treated with dicyclohexylamine in Me Et ketone/methanol (5:1) to precipitate the crystalline salt that contains I of >99% ee in 22% overall yield from II.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Muller, Giel; Scheer, Adam; Osborn, David L.; Taatjes, Craig A.; Meloni, Giovanni researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).Formula: C6H10O3.They published the article 《Low Temperature Chlorine-Initiated Oxidation of Small-Chain Methyl Esters: Quantification of Chain-Terminating HO2-Elimination Channels》 about this compound( cas:37443-42-8 ) in Journal of Physical Chemistry A. Keywords: small chain methyl ester low temperature chlorine initiated oxidation. We’ll tell you more about this compound (cas:37443-42-8).

Cl-initiated oxidation reactions of three small-chain Me esters, Me propanoate (CH3CH2COOCH3; MP), Me butanoate (CH3CH2CH2COOCH3; MB), and Me valerate (CH3CH2CH2CH2COOCH3; MV), are studied at 1 or 8 Torr and 550 and 650 K. Products are monitored as a function of mass, time, and photoionization energy using multiplexed photoionization mass spectrometry coupled to tunable synchrotron photoionization radiation. Pulsed photolysis of mol. chlorine is the source of Cl radicals, which remove an H atom from the ester, forming a free radical. In each case, after addition of O2 to the initial radicals, chain-terminating HO2-elimination reactions are observed to be important. Branching ratios among competing HO2-elimination channels are determined via absolute photoionization spectra of the unsaturated Me ester coproducts. At 550 K, HO2-elimination is observed to be selective, resulting in nearly exclusive production of the conjugated Me ester coproducts, Me propenoate, methyl-2-butenoate, and methyl-2-pentenoate, resp. However, in MV, upon raising the temperature to 650 K, other HO2-elimination pathways are observed that yield Me 3-pentenoate and Me 4-pentenoate. In each Me ester oxidation reaction, a peak is observed at a mass consistent with cyclic ether formation, indicating chain-propagating OH loss/ring formation pathways via QOOH intermediates. Evidence is observed for the participation of resonance-stabilized QOOH in the most prominent cyclic ether pathways. Stationary point energies for HO2-elimination pathways and select cyclic ether formation channels are calculated at the CBS-QB3 level of theory and assist in the assignment of reaction pathways and final products.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics