Category: 374554-89-9

374554-89-9, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 374554-89-9

5- And/or 7-substituted pyrazolo-[4,3-b]-pyridines and their use as antiinflammatory agents

Compounds of the formula (I) and pharmaceutically acceptable salts thereof: STR1 wherein: the first of R1 and R2 is hydrogen, C1-4 alkyl or phenyl optionally substituted by one or two substituents selected from halogen, CF3, C1-4 alkoxy or alkyl and the second is SR4 wherein R4 is phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl, or NR5 R6 wherein R5 and R6 are independently selected from hydrogen, C1-6 alkyl, C3-8 cycloalkyl, phenyl or phenyl C1-4 alkyl either of which phenyl moieties may be substituted by one or two substituents selected from halogen, CF3, C1-4 alkoxy or C1-4 alkyl, or R5 and R6 together form C4-6 polymethylene; and R3 is hydrogen, C1-4 alkyl or benzyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory activity, a process for their preparation and their use as pharmaceuticals.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 374554-89-9, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 374554-89-9

Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

374554-89-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 374554-89-9, molcular formula is C7H3ClFNO, introducing its new discovery.

Certain anti-inflammatory pyrazolo [4,3-b] pyridine 7-amines

A compound of the formula (1) or a salt or solvate thereof: STR1 in which: R0 is hydrogen or C1-6 alkyl; R1 and R2 are both hydrogen; or R1 is hydrogen, C1-6 alkyl; and R2 is CN; CR5 R6 Y where R5 and R6 are independently selected from hydrogen and C1-4 alkyl and Y is selected from hydrogen, OR7 or SR7 where R7 is hydrogen, C1-4 alkyl or C2-4 alkanoyl, and NR8 R9 where R8 and R9 are independently hydrogen, C1-4 alkyl, C2-4 alkenyl or C2-4 alkanoyl or together are C4-6 polymethylene; or COR10 is OH or C1-4 alkyl, or COR10 is a pharmaceutically acceptable ester or amide; or R2 is hydrogen, C1-6 alkyl, or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl; and R1 is CN, CR5 R6 Y or COR10 as defined for R2 above; or R1 and R2 together form C3 -C6 polymethylene optionally substituted by C1 -C4 alkyl; R3 is –(CH2)n CO2 R11, –(CH2)n CONR12 R13,–(CH2)n CN, –(CH2)m NHCOR14, STR2 where a, b, n, m and p are integers and n is 1 to 10, m is 2 to 10, p is 3 to 5, a is 1 to 3, and b is 1 to 3, and R11 is hydrogen, C1-8 alkyl, benzyl or phenyl, R12 and R13 are independently hydrogen, C1-6 alkyl, benzyl or phenyl, or together form C3-8 alkylene, R14 is C1-4 alkyl, benzyl or phenyl and X is oxygen, sulphur, NH or N–C1-4 alkyl, and R4 is hydrogen; or C1-4 alkyl or benzyl optionally substituted in the phenyl ring by one or two of halogen, CF3, C1-4 alkoxy or C1-4 alkyl, and is attached at nitrogen atom 1 or 2, a process for its preparation and its use as a pharmaceutical.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 374554-89-9, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 374554-89-9

Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

374554-89-9, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 374554-89-9

Pharmaceutically useful pyrazolo[4,3-b]pyridines

A compound of the formula (I) or a salt or solvate thereof: STR1 in which: R0 is hydrogen or C1-6 alkyl; or together with R3 is C4-6 polymethylene; R1 and R2 are both hydrogen; or R1 is hydrogen, C1-6 alkyl; and R2 is CN; CR5 R6 Y where R5 and R6 are independently selected from hydrogen and C1-4 alkyl and Y is selected from hydrogen, OR7 or SR7 where R7 is hydrogen, C1-4 alkyl or C2-4 alkanoyl, and NR8 R9 where R8 and R9 are independently hydrogen, C1-4 alkyl, C2-4 alkenyl or C2-4 alkanoyl or together are C4-6 polymethylene; or COR10 where R10 is OH or C1-4 alkyl, or COR10 is a pharmaceutically acceptable ester or amide, or R2 is hydrogen, C1-6 alkyl, or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl, and R1 is CN, CR5 R6 Y or COR10 as defined for R2 above; or R1 and R2 together form C3 -C6 polymethylene optionally substituted by C1 -C4 alkyl; R3 is hydrogen; or C1-10 alkyl or C3-10 cycloalkyl, either optionally substituted by hydroxy, C1-4 alkoxy, thiol, C1-4 alkylthio or NR11 R12 wherein R11 and R12 are independently hydrogen, C1-6 alkyl or C2-7 alkanoyl or together are C3-6 polymethylene; C2-10 alkenyl; or phenyl optionally substituted by one or two of halogen, CF3, C1-4 alkoxy, C1-4 alkyl, hydroxy, nitro, cyano, C2-10 acyloxy, NR13 R14 wherein R13 and R14 are independently selected from hydrogen, C1-6 alkyl, or C2-7 alkanoyl; or COR15 wherein R15 is hydroxy, C1-6 alkoxy or NR16 R17 wherein R16 and R17 are independently selected from hydrogen or C1-6 alkyl; or R3 is a mono- or fused bi-cyclic heteroaryl group having up to ten atoms in the aromatic ring(s), not more than two of which are selected from nitrogen, oxygen or sulphur, other than those containing basic nitrogen, optionally substituted by one or two substituents selected from halogen, CF3, C1-4 alkoxy, C1-4 alkyl, hydroxy, nitro, cyano, C2-10 acyloxy, NR23 R24 wherein R23 and R24 are independently selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl; or COR25 wherein R25 is hydroxy, C1-6 alkoxy or NR26 R27 wherein R26 and R27 are independently selected from hydrogen or C1-6 alkyl; R4 is hydrogen, or C1-4 alkyl, phenyl or benzyl, each of which is optionally substituted in the phenyl ring by one or two of halogen, CF3, C1-4 alkoxy or C1-4 alkyl and is attached at nitrogen atom 1 or 2; and Rx is C1-6 alkyl, halogen, nitro, NR18 R19 where R18 and R19 are independently hydrogen, C1-6 alkyl or C2-7 alkanoyl, nitrile, COOH, CONH2 ; phenyl or benzyl optionally substituted by one or two of halogen, nitro, C1-6 alkoxy, hydroxy, C2-7 alkanoyloxy, NR18 R19, C1-6 alkyl, CF3, CN; thienyl, furyl or pyrryl optinoally N-substituted by C1-6 alkyl, with the proviso that R0 and R3 are not both hydrogen when R1 is hydrogen and R2 and Rx are methyl, is useful for treating inflammatory or allergic conditions.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 374554-89-9, name is 3-Chloro-6-fluorobenzo[d]isoxazole, introducing its new discovery. 374554-89-9

Pyrazolopyridine derivatives and their use as anti-inflammatory and/or anti-allergic agents

Compounds of formula (I) and pharmaceutically acceptable salts thereof: STR1 wherein: R1 is hydrogen, C1-6 alkyl or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is hydroxy, nitro, cyano, C2-10 acyloxy, NR6 R7 wherein R6 and R7 are independently selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl; or COR8 wherein R8 is hydroxy, C1-6 alkoxy or NR9 R10 wherein R9 and R10 are independently selected from hydrogen or C1-6 alkyl; R4 is hydrogen, halogen, CF3, C1-4 alkoxy, C1-4 alkyl or any of the groups listed for R3 ; and R5 is hydrogen, C1-4 alkyl or benzyl optionally substituted in the phenyl ring by halogen, CF3, C1-4 alkoxy or C1-4 alkyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory and/or anti-allergy activity, and their use as pharmaceuticals.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.374554-89-9, you can also check out more blogs about374554-89-9

Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics