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BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS

This invention relates to novel benzisoxazole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels e.g. a respiratory disease, epilepsy or convulsions. X represents a subsituent selected from the group consisting of CO-NR”R””, CO-O-R”, CO-NH-S, CO-NH-SO2R”””, CO-NH-C=N, SO2-NR”R””, 2,3-dihydro-1-H-tetrazol-5-yl and [1, 2, 4]oxadiazolidin-5-one; wherein R” and R””, independently of each other, represent hydrogen or alkyl or phenyl; and R””” represents alkyl, cycloalkyl, haloalkyl or phenyl, which phenyl may optionally be substituted one or more times with substituents selected from halo, trifluoromethyl, trifluoromethoxy, cyano and nitro.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION

The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Extracurricular laboratory:new discovery of 1,2-Benzisoxazole-3-acetic Acid

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4865-84-3, name is 1,2-Benzisoxazole-3-acetic Acid, introducing its new discovery. Application In Synthesis of 1,2-Benzisoxazole-3-acetic Acid

Recent advances in 4-hydroxycoumarin chemistry. Part 2: Scaffolds for heterocycle molecular diversity

The present paper aims to review the synthetic applicability of 4-hydroxycoumarin in heterocyclic synthesis during the period from 1996 up to now. This compound can be used as building blocks for five, six, and seven-membered heterocycles as well as fused rings.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 4865-84-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4865-84-3, name is 1,2-Benzisoxazole-3-acetic Acid. In an article£¬Which mentioned a new discovery about 4865-84-3

A PROCESS FOR THE MANUFACTURE OF ZONISAMIDE

The present invention describes an improved process for the preparation of 1,2Benzisoxazole-3-methanesulphonamide (Zonisamide), a well known anti-epileptic agent which possesses anti-convulsant and anti-neurotoxic effects. Other aspect of this invention are isolation of a key intermediate, viz., crystalline sodium chloride associated 1,2Benzisoxazole-3-methane sodium sulfonate (BOS-Na:NaCl). The isolated crude BOSNa:NaCl is directly converted to Zonisamide using controlled molar ratio of chlorosulfonic acid to avoid the disulfonated side products. The analytical characteristics like IR and XRD data of the BOS-Na:NaCl are also reported to confirm its nature.

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Benzisoxazole – Wikipedia,
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Can You Really Do Chemisty Experiments About 1,2-Benzisoxazole-3-acetic Acid

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 1,2-Benzisoxazole-3-acetic Acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4865-84-3, Name is 1,2-Benzisoxazole-3-acetic Acid, molecular formula is C9H7NO3

2-Cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid ester derivatives, process for the preparation thereof and composition containing the same

Novel 2-cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid derivatives of the formula: STR1 wherein R1 is hydrogen or a halogen atom, R2 is a lower alkyl group, Am is a 5- to 9-membered saturated cyclic amino group which may be substituted by a lower alkyl group, and the group: STR2 binds to the piperidine moiety at 3- or 4-position of the latter, and their pharmaceutically acceptable acid addition salts and quaternary ammonium salts, process for their preparation, and pharmaceutical compositions containing these compounds. They have potent anticholinergic antispasmodic activity, while they are weak in side effects such as mydriasis, inhibition of salivary secretion and tachycardia.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Adeninic and ureidic cytokinins: Primary response events in in vitro tomato caulogenesis

Among the molecules showing cytokinin activity, phenylurea derivatives have been long discussed as regards their direct or indirect action in cytokinin-mediated processes. This paper considers the activity of three cytokinins, an adenine and two phenylurea derivatives, on the caulogenesis onset. Caulogenesis is composed of sequential stages involving peculiar hormonal requirements and the differential activation of genes that can be considered markers of the steps leading to shoot production. Our study shows that the expression of LESK1, marker of caulogenic competence acquisition, is induced by both adeninic and ureidic derivatives, indicating that morphogenesis is induced by these molecules through the activation of common components of response pathway. The detailed analysis on morphogenesis in a system deprived of endogenous cytokinins strengthen the hypothesis of a proper cytokinin activity for the two phenylurea derivatives, 1-phenyl-3-(1,2,3-thiadiazol-5-yl)urea (thidiazuron TDZ) and N-phenyl-N?-benzothiazol-6-ylurea (PBU). A different behaviour of zeatin riboside (ZR), TDZ and PBU, emerges when the growth regulator supply is preceded by a 3-day pre-culture which positively affects the caulogenesis obtained with TDZ, while it strongly inhibits the action of ZR. PBU activity instead resulted more similar to that of the cytokinin/auxin treatment, supporting the idea of an interaction of diphenylurea derivatives with auxin metabolism. The synergistic effect of auxin on shoot production emerges from both the higher rate of caulogenic competence acquisition, marked by a sharper peak of LESK1 expression, which leads to a strong increase in shoot number produced per explant when cytokinin and auxin are supplied together.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Archives for Chemistry Experiments of 4865-84-3

Safety of 1,2-Benzisoxazole-3-acetic Acid, We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 4865-84-3,and how the biochemistry of the body works.

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1,2-BENZISOXAZOLE-3-METHANE-SULFONIC ACID AMMONIUM SALT

The present invention provides substantially isolated ammonium salt of 1,2- benzisoxazole-3-methane sulfonic acid (BOS-NH4), which can be crystalline. The present invention also provides substantially chemically pure BOS-NH4, which is non- hygroscopic or slightly hygroscopic. Another aspect of the present invention is directed to processes of preparing the BOS-NH4. The present invention also provides processes for preparing l,2-benzisoxazole-3-methane-sulfonyl chloride (BOS-Cl) using the BOS-NH4. The present invention also provides processes for preparing zonisamide using the BOS-NH4 or BOS-Cl.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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The expression of LESK1 morphogenetic marker along the tomato hypocotyl axis is linked to a position-dependent competence for shoot regeneration

Somatic morphogenesis is an important process whose mechanisms are still not completely understood. This is partially due to the lack of reliable morphogenetic markers that identify the different stages of the process. In the present work, a fragment of LESK1 gene (Lycopersicon esculentum shoot kinase 1) has been utilized as a marker of somatic caulogenesis. The expression of this marker pointed out a particular abundance of the corresponding transcript in tomato hypocotyls from 8-day-old plantlets. This elevated expression underlines the particular attitude to regeneration of this organ. Hypocotyl explants can in fact regenerate in the absence of exogenous growth regulators giving rise to shoot and root production at the apical and basal ends, respectively. The polarization observed in morphogenesis is always associated with polarized expression of LESK1 gene, which is elevated at the top of the explants, where shoot production occurs, and low at the basal pole, where roots were observed. A non-homogeneous LESK1 expression was also found along the hypocotyl axis where apparently marks cell populations with different competence to caulogenesis. These different levels of competence may be due to a variation in cell sensitivity to growth regulators, or the reaching of a well determined hormonal ratio required by the cells to be driven toward caulogenesis. LESK1 represents a reliable marker probably linked to the acquisition of competence for somatic caulogenesis.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C9H7NO3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4865-84-3, in my other articles.

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Docking studies of some 2-(benzo[d] isoxazole-3-yl)-N-(oxothiazolidine) derivative with COX-II and thromboxane as target protein and evaulation of its anti inflammatory activty

A scaffold of ten thiazolidinone derivatives of 1,2-Benzisoxazole [5a-5j] were synthesized using 4-Hydroxy-2H-chromen-2-one as the starting material. The synthesis was carried out by conventional technique and the synthesized compounds were identified by physical methods and their structures characterized by spectral analysis. The identified compounds were further subjected to docking studies using two proteins, COX-2 and thromboxane which are known as mediators of inflammation. All the compounds showed good docking scores indicating that they are potent inhibitors of COX-2 and thromboxane. In line with the above result, invitro anti-inflammatory studies were carried out on the moieties by HRBC membrane stabilization method using diclofenac as standard. Significant anti-inflammatory activity was observed in compounds 5a, 5b, 5c, 5f, 5g and 5i.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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SYNTHESIS OF 4-OXO-4H-BENZISOXAZOLO<2,3-a>PYRIDINES VIA DIMERIZATION OF 1,2-BENZISOXAZOLE-3-ACETIC ACIDS

Reactions of 1,2-benzisoxazole-3-acetic acid (1) with tosyl chloride and acyl chlorides in pyridine afforded the corresponding 4-oxo-4H-benzisoxazolo<2,3-a>pyridines (2).KEYWORDS – 1,2-benzisoxazole-3-acetic acids; dimerization; mixed anhydrides; tosyl chloride; N-C bond formation; 4-oxo-4H-benzisoxazolo<2,3-a>pyridines

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics