Category: 532-32-1

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of Sodium benzoate, 532-32-1, Name is Sodium benzoate, SMILES is O=C([O-])C1=CC=CC=C1.[Na+], belongs to Benzisoxazole compound. In a document, author is Brown-Proctor, C, introduce the new discover.

Synthesis and evaluation of 6-[C-11]methoxy-3-[2-[l-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole as an in vivo radioligand for acetylcholinesterase

6-Methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole is a high affinity (K-i = 8.2 nM) reversible inhibitor of acetylcholinesterase (AChE). The carbon-11 labeled form was prepared in high (>97%) radiochemical purity and with specific activities of 37 +/- 20 GBq/mu mol at end of synthesis, by the alkylation of the desmethyl precursor with [C-11]methyl trifluoromethanesulfonate in N,N dimethylformamide at room temperature. In vivo studies in mice demonstrated good blood brain permeability but essentially uniform regional brain distribution. Thus, despite in vitro and in vivo activity as an AChE inhibitor, 6-[C-11]methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole does not appear to be a good candidate for in vivo imaging studies of AChE in the mammalian brain. NUCL MED BIOL 26;1: 99-103, 1999. (C) 1999 Elsevier Science Inc.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 532-32-1 is helpful to your research. Application In Synthesis of Sodium benzoate.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In an article, author is Chimichi, Stefano, once mentioned the application of 532-32-1, Name: Sodium benzoate, Name is Sodium benzoate, molecular formula is C7H5NaO2, molecular weight is 144.1032, MDL number is MFCD00012463, category is Benzisoxazole. Now introduce a scientific discovery about this category.

First example of diels-alder reaction of 4-(1-ethenylsubstituted)-3-methylisoxazoles with acetylenedicarboxylates

The first example of a [4+2] cycloaddition reaction of 4-(1-ethenylsubstituted)isoxazoles with acetylenedicarboxylates is reported, while the corresponding 5-substituted isomers do not react with the same dienophile; density functional theory (DFT) calculation indicate the electronic origin of the different behaviour.

If you are interested in 532-32-1, you can contact me at any time and look forward to more communication. Name: Sodium benzoate.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics