Category: 57-11-4

Chemistry is an experimental science, Safety of Stearic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 57-11-4, Name is Stearic acid, molecular formula is C18H36O2, belongs to benzisoxazole compound. In a document, author is Akbar, Sikkandarkani.

A Tandem Strategy for the Synthesis of 1H-Benzo[g]indazoles and Naphtho[2,1-d]isoxazoles from o-Alkynylarene Chalcones

o-Alkynylarene chalcones when treated with hydrazines and hydroxylamine in the presence of iodine gave 1H-benzo[g]indazoles and naphtho[2,1-d]isoxazoles, respectively. The transformations involve tandem oxidative cyclocondensation/electrophilic hydroarylation. The methodology was applied to quinoline-based chalcones, which also afforded the corresponding quinoline-fused benzindazole and benzisoxazole.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 57-11-4, in my other articles. Safety of Stearic acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 57-11-4, Name is Stearic acid, molecular formula is C18H36O2. In an article, author is Kitamura, S,once mentioned of 57-11-4, Safety of Stearic acid.

The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide

Zonisamide (1,2-benzisoxazole-3-methanesulphonamide), a new anticonvulsant, is mainly metabolized to 2-sulphamoylacetylphenol by reduction of the benzisoxazole ring. Recent studies have shown that mammalian liver enzymes are responsible for the reduction of zonisamide. Because intestinal bacteria can also mediate the reduction of xenobiotics, this study was designed to evaluate the role of intestinal bacteria in in-vivo reductive metabolism of zonisamide. Treatment of rats with antibiotics significantly reduced the urinary and faecal excretion of 2-sulphamoylacetylphenol after oral administration of zonisamide. Re-contamination of the antibiotic-treated rats with microflora restored the excretion of the metabolite. The caecal contents of the control rats had significant zonisamide reductase activity, whereas little or no zonisamide reductase activity was observed with the caecal contents of the antibiotic-treated rats. Eight pure strains of intestinal bacteria were tested for zonisamide reductase activity and the highest was observed in Clostridium sporogenes. We concluded that intestinal bacteria play a major role in the reductive metabolism of zonisamide to 2-sulphamoylacetylphenol in-vivo.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 57-11-4, Name is Stearic acid. In a document, author is De Simone, G, introducing its new discovery. Product Details of 57-11-4.

Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies

The antiepileptic drug zonisamide was considered to act as a weak inhibitor of the zinc enzyme carbonic anhydrase (CA, EC 4.2. 1.1) (with a K, of 4.3 mu M against the cytosolic isozyme 11). Here we prove that this is not true. Indeed, testing zonisamide in the classical assay conditions of the CO2 hydrase activity of hCA II, with incubation times of enzyme and inhibitor solution of 15 min, a K-1 of 10.3 mu M has been obtained. However, when the incubation between enzyme and inhibitor was prolonged to 1d h, the obtained K-1 was of 35.2 nM, of the same order of magnitude as that of the clinically used sulfonamides/sulfamates acetazolantide, methazolamide, ethoxzolamide and topiramate (K(1)s in the range of 5.4-15.4 nM). The inhibition of the human mitochondrial isozyme hCA V with these compounds has been also tested by means of a dansylamide competition binding assay, which showed zonisamide and topiramate to be effective inhibitors, with K(1)s in the range of 20.6-25.4 nM. The X-ray crystal structure of the adduct of hCA 11 with zonisamide has also been solved at a resolution of 1.70 A, showing that the sulfonamide moiety participates in the classical interactions with the Zn(II) ion and the residues Thr199 and Glu106, whereas the benzisoxazole ring, is oriented toward the hydrophobic half of the active site, establishing a large number of strong van der Waals interactions (< 4.5 A) with residues Gln92, Vall2l, Phe131, Leu198, Thr200, Pro202. (c) 2005 Elsevier Ltd. All rights reserved. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 57-11-4 help many people in the next few years. Product Details of 57-11-4.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

57-11-4, Name is Stearic acid, molecular formula is C18H36O2, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Mahindroo, N, once mentioned the new application about 57-11-4, SDS of cas: 57-11-4.

Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities

The synthesis and structure-activity relationship studies of novel indole derivatives as peroxisome proliferator-activated receptor (PPAR) agonists are reported. Indole, a druglike scaffold, was studied as a core skeleton for the acidic head part of PPAR agonists. The structural features (acidic head, substitution on indole, and linker) were optimized first, by keeping benzisoxazole as the tail part, based on binding and functional activity at PPAR gamma protein. The variations in the tail part, by introducing various heteroaromatic ring systems, were then studied. In vitro evaluation led to identification of a novel series of indole compounds with a benzisoxazole tail as potent PPAR agonists with the lead compound 14 (BPR1H036) displaying an excellent pharmacokinetic profile in BALB/c mice and an efficacious glucose lowering activity in KKA(y) mice. Structural biology studies of 14 showed that the indole ring contributes strong hydrophobic interactions with PPAR gamma and could be an important moiety for the binding to the protein.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Electric Literature of 57-11-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 57-11-4, Name is Stearic acid, SMILES is CCCCCCCCCCCCCCCCCC(O)=O, belongs to benzisoxazole compound. In a article, author is Sano, Hiromi, introduce new discover of the category.

The effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson’s disease model mice

Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain and shows motor dysfunctions. Zonisamide (ZNS, 1,2-benzisoxazole-3-methanesulfonamide), which was originally developed as an antiepileptic drug, was also found to have beneficial effects on motor symptoms in PD. In the current study, we have investigated the behavioral and physiological effects of ZNS on L-DOPA-induced dyskinesia (LID) in PD model mice. Chronic administration of L-DOPA plus ZNS in PD model mice was shown to increase the duration and severity of LID compared with PD model mice that were treated with L-DOPA alone. To elucidate the neural mechanism of the effects of ZNS on LID, we examined neuronal activity in the output nuclei of the basal ganglia, i.e., the substantia nigra pars reticulata (SNr). Chronic administration of L-DOPA plus ZNS in PD mice decreased the firing rate in the SNr while they showed apparent LID. In addition, chronic treatment of L-DOPA plus ZNS in PD mice changed cortically evoked responses in the SNr during LID. In the control state, motor cortical stimulation induces the triphasic response composed of early excitation, inhibition, and late excitation. In contrast, L-DOPA plus ZNS-treated PD mice showed longer inhibition and reduced late excitation. Previous studies proposed that inhibition in the SNr is derived from the direct pathway and releases movements, and that late excitation is derived from the indirect pathway and stops movements. These changes of the direct and indirect pathways possibly underlie the effects of ZNS on LID.

Electric Literature of 57-11-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 57-11-4.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 57-11-4, Name is Stearic acid, molecular formula is C18H36O2. In an article, author is YOSHII, K,once mentioned of 57-11-4, Recommanded Product: 57-11-4.

BETA-RIBONUCLEOSIDES AND ALPHA-ARABINONUCLEOSIDES CONTAINING THE 1,2-BENZISOXAZOLE AND 1,2-BENZISOTHIAZOLE RINGS

The reaction of the silylated base of 1,2-benzisoxazol-3(2H)-one (1) and its 7-methyl derivative 5 and 5-methyl-1,2-benzisothiazol-3(2H)-one (9), respectively, with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose followed by basic deprotection gave the corresponding beta-D-ribonucleosides, and the silylated base of 1, when treated with 1-O-acetyl-2,3,5-tri-O-benzoyl-alpha-D-arabinofuranose in the presence of stannic chloride, afforded the corresponding alpha-arabinonucleoside. Structural proofs of these nucleosides are provided from elemental analyses and H-1 and C-13 nmr spectra.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry is an experimental science, Application In Synthesis of Stearic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 57-11-4, Name is Stearic acid, molecular formula is C18H36O2, belongs to benzisoxazole compound. In a document, author is MEWSHAW, RE.

BRIDGED GAMMA-CARBOLINES AND DERIVATIVES POSSESSING SELECTIVE AND COMBINED AFFINITY FOR 5-HT2 AND D(2)-RECEPTORS

A series of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles and 6,7,8,9,10,11-hexahydro-7,-11-imino-5H-cyclooct[b]indoles was prepared. Structural modifications of the lead compound, 11-[4-(4-fluorobenzoyl)propyl]-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole (5, K(i) = 0.82 nM vs [H-3]ketanserin) enabled the identification of the functionality necessary for high affinity at serotonin 5-HT2 and dopamine D2 receptors in ligand binding studies. The indole ring, as well as the benzoyl or isosteric benzisoxazole moiety, were essential for high affinity. Variations of the length of the side chains resulted in ligands having either selective affinity for the 5-HT2 receptor or a combination of 5-HT2 and D2 affinity. In vivo binding studies were performed on selected members in this series. The most potent member, 2-fluoro-11-[4-(4-fluorobenzoyl)butyl]-5,6,7,8,9,-10-hexahydro-7,10-iminocyclohept[b]indole (36) had an ED50 of <1 mg/kg at the 5-HT2 and D2 receptors following oral administration. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 57-11-4, in my other articles. Application In Synthesis of Stearic acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 57-11-4, Name is Stearic acid, molecular formula is C18H36O2. In an article, author is Umamaheswari, J.,once mentioned of 57-11-4, Formula: C18H36O2.

Efficient Antimicrobial Activities of Microwave-assisted Synthesis of Benzisoxazole Derivatives

The present study deals with the synthesis of benzisoxazole derivatives beginning from 5,5-dimethyl cyclohexane-1,3-dione by making use of a microwave reactor. The microwave reactions are effortless, well-organized, clean, swift and financially viable for the synthesis of a huge amount of organic molecules, have offered the drive for many chemists to change from conventional heating methods to microwave-assisted chemistry. In latest years, microwave synthesized organic reaction has appeared as a new device in organic synthesis. The synthesized compounds were for the studie by using IR, NMR, mass spectra and antimicrobial studies also carried out.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

57-11-4, Name is Stearic acid, molecular formula is C18H36O2, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Comanita, E, once mentioned the new application about 57-11-4, Safety of Stearic acid.

Synthesis and reactivity of some Mannich bases. VII. Synthesis of 3-(2-dialkylaminoethyl)-1,2-benzisoxazoles

3-(2-Dialkylaminoethyl)-1,2-benzisoxazoles (2) are accessible by direct cyclization of the corresponding Mannich bases oxime acetates (11) in refluxing benzene in the presence of anhydrous potassium carbonate. The previously known methods for ring closure to 1,2-benzisoxazole were ineffective for this class of pharmacologically relevant compounds.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In an article, author is Soman, Shubhangi S., once mentioned the application of 57-11-4, COA of Formula: C18H36O2, Name is Stearic acid, molecular formula is C18H36O2, molecular weight is 284.4773, MDL number is MFCD00002752, category is Benzisoxazole. Now introduce a scientific discovery about this category.

Synthesis of new naphthoisoxazole amide derivatives and study of their biological evaluations

A series of naphthoisoxazole amide derivatives 4a-h have been synthesized from naphthoisoxazole acetic acid 3. 2-Acetyl-1-naphthol-1 on reaction with pulverized sodium and diethyl carbonate gave 4-hydroxy naphthopyrone 2 which on Posner reaction gave naphthoisoxazole acetic acid 3. The cytotoxic activity study for inhibiting melanoma cell survival was evaluated on a series of melanoma cell lines. The anticonvulsant activity of these compounds has been evaluated in Wistar rats. A compound called 4h has been found to have anticonvulsant activity comparable to that of the standard drug phenytoin.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics