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SULFAMATO HYDROXAMIC ACID METALLOPROTEASE INHIBITOR

A sulfamato hydroxamic acid compound that, inter alia, inhibits matrix metalloprotease (mmp) activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a contemplated sulfamato hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Radiopaque dental materials

Highly esthetic dental compositions have both good radiopacity and optical opacity. It has been found that the addition of bismuth fluoride to dental material compositions provides these desirable properties. Bismuth fluoride is relatively inexpensive and easily obtainable.

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Benzisoxazole – Wikipedia,
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Bone cement in paste form

A kit comprises paste (A) and paste (B). The paste (A) contains radical polymerizable monomer(s) (a1), peroxide(s) (a2) and tertiary amine(s) (a3). The paste (B) contains radical polymerizable monomer(s) (b1), heavy metal compound(s) (b2), and sulfimide(s) and/or dicarboxylic acid imide(s) (b3) as copolymer ion accelerator. The pastes (A) and (B) contains filler as component (a4) and/or (b4), respectively. The filler is insoluble in radical polymerizable monomer(s) (a1) and/or (b1). A kit comprises paste (A) and paste (B). The paste (A) contains radical polymerizable monomer(s) (a1) having boiling point of less than 120[deg] C under pressure of 1.013 mbar, peroxide(s) (a2) as polymerization initiator, and tertiary amine(s) and/or amidine(s) (a3) as copolymer ion accelerator. The paste (B) contains radical polymerizable monomer(s) (b1) having boiling point of less than 120[deg] C under pressure of 1.013 mbar, heavy metal compound(s) (b2) as polymerization accelerator, and sulfimide(s) and/or dicarboxylic acid imide(s) (b3) as copolymer ion accelerator. The pastes (A) and (B) contains filler as component (a4) and/or (b4), respectively. The filler is insoluble in radical polymerizable monomer(s) (a1) and/or (b1). An independent claim is included for molded product, which is obtained by polymerization of paste obtained by mixing paste (A) and paste (B) of the kit.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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ACRYLATED URETHANES, PROCESSES FOR MAKING THE SAME AND CURABLE COMPOSITIONS INCLUDING THE SAME

The present invention is directed to acrylated urethanes including the reaction product of: (1)(a) at least one urethane having at least two isocyanate groups and at least one acrylate group; and (b) at least one alcohol compound having at least two hydroxyl groups; or (2) (a) at least one isocyanate functional urethane which is the reaction product of at least one alcohol compound selected from the group consisting of amino alcohols, thioether alcohols, phosphino alcohols and mixtures thereof and at least one polyisocyanate; and (b) at least one hydroxy-functional material having at least one acrylate group; curable compositions including the same and processes for making the same.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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VEHICLE BODY FILLER COMPRISING AN UNSATURATED POLYESTER RESIN

The present invention relates to a curable filler composition suitable for smoothening a metal surface, in particular a metal surface of a vehicle body, wherein the filler composition comprises a resin composition and a curing composition reactive with the resin composition, which resin composition and curing composition are provided to be mixed upon application of the filler composition to the surface to be smoothened, wherein the resin composition comprises – 5.0 to 35.0 wt. %, preferably 10.0-25.0 wt. % of a reactive component which becomes an integral part of the composition on curing, – 50.0 to 80.0 wt. % of a polyester formed from a reaction of an a,beta-unsaturated dibasic acid and/or anhydride, with one or more polyhydric alcohols, and wherein the curing composition contains a mixture of a cumyl hydro peroxide catalyst and a dibenzoyl peroxide catalyst.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Curable composition

A curable composition comprising: (A) 100 parts by mass of a monomer component which comprises a radically polymerizable monomer and has a water absorbing capacity of not larger than 20% by weight; (B) 0.5 to 10 parts by mass of water; (C) 0.1 to 20 parts by mass of a surfactant; and (D) an effective amount of a radical polymerization initiator. The curable composition is cured by polymerization in a state where a water layer is formed on the surfaces of the cured body that is being formed, effectively suppressing the hindrance of polymerization caused by oxygen and decreasing the formation of unpolymerized product on the surfaces of the cured body. The curable composition is particularly useful as a dental restorative.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Synthesis of beta-amino alcohols from aromatic amines and alkylene carbonates using Na-Y zeolite catalyst

A simple, efficient, and environmentally benign methodology for the synthesis of beta-amino alcohols from aromatic amines and alkylene carbonates in the presence of the highly active and reusable solid base catalyst Na-Y zeolite is demonstrated. Georg Thieme Verlag Stuttgart.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Different peripheral substituted phthalocyanines: Synthesis, characterization, aggregation behavior, antioxidant and antibacterial activity

In this study, a novel phthalonitrile, 4-chloro-5-(2-((2-hydroxyethyl)(p-tolyl)amino)ethoxy)phthalonitrile (3), and its metallophthalocyanine derivatives (4-6) are prepared by cyclotetramerization with appropriate metal salts in dimethylformamide. The newly prepared compounds have been characterized by several spectroscopic techniques. All compounds are evaluated for their antioxidant and antibacterial potential. For the antioxidant studies, three tests are applied; DPPH (2,2-diphenyl-1-picrylhydrazylradical) scavenging, metal chelating and reducing power activity. Compound 4 exhibits the best DPPH scavenging activity as 35.2% at 100 mg/L concentration. The metal chelating activities of compounds 3 and 4 are 69.7% and 56.4%, respectively. Reducing power activities of compounds 3 and 4 are higher than alpha-tocopherol which is used as positive control. All compounds show moderate antibacterial activity when compared to the standard antibiotics, amikacin and tetracycline.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Dental self-curing resin cement compositions

The present invention refers to dental self-curing resin compositions having enhanced mechanical and physical properties. In particular, the present invention relates to dental self-curing resin compositions consisting of (i) a Paste A composition containing the multifunctional prepolymer mixture of 2,2-bis-[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (?Bis-GMA?) and multifunctional prepolymer formed by substituting hydrogen atoms in hydroxyl group with methacrylate groups in the Bis-GMA molecules, and further containing a diluent, an adhesive monomer, a polymerization initiator, a polymerization inhibitor, a light stabilizer, an antioxidant, an inorganic pigment and an inorganic filler; and ii) a Paste B composition containing the same prepolymer mixture in the Paste A composition, and further containing a diluent, an adhesive monomer, a reductant, a polymerization inhibitor, a light stabilizer, an antioxidant, an inorganic pigment and an inorganic filler. The composition according to the present invention has better physical and mechanical properties than that of conventional compositions and is an ointment-ointment system able to be conveniently used.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Dental compositions

A two part composition for sealing and/or filling root canals. One or more elastomeric (meth)acrylate oligomers are mixed with one or more diluent comonomers, one or more radiopaque fillers and one or more polymerization initiator systems. One or more antimicrobial agents may also be included in the composition. The components are mixed, undergo a setting reaction and are subsequently cured. In use, the composition is easily removed from the tooth structure if rework is needed, yet provides a tight and effective seal in the root canal. The composition also has a desirable flowable consistency and exhibits good adhesiveness with a tooth substrate.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics