Category: 701-97-3

In an article, author is Abou El-Magd, R. M., once mentioned the application of 701-97-3, Name is 3-Cyclohexylpropionic Acid, molecular formula is C9H16O2, molecular weight is 156.2221, MDL number is MFCD00001527, category is benzisoxazole. Now introduce a scientific discovery about this category, Category: Benzisoxazole.

The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia

D-Amino acid oxidase (DAO) has been established to be involved in the oxidation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the brain, and to be associated with the onset of schizophrenia. The effect of risperidone, a benzisoxazole derivative, atypical antischizophrenic drug, on the activity of human DAO was tested using an in-vitro oxygraph system and rat C6, stable C6 transformant cells overexpressing mouse DAO (designated as C6/DAO) and pig kidney epithelial cells (LLC-PK1). Risperidone has a hyperbolic mixed- type inhibition, designated as ‘partial uncompetitive inhibition effect’, with K-i value of 41 mu M on human DAO. Risperidone exhibited a protective effect from D-amino acid induced cell death in both C6/DAO and LLC-PK1 cells with 10% increase in viability. These data indicate the involvement of DAO activity in D-serine metabolism and also suggest a new mechanism of action to risperidone as antischizophrenic drug.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 701-97-3, Name is 3-Cyclohexylpropionic Acid, molecular formula is C9H16O2. In an article, author is Kumbhare, Ravindra M.,once mentioned of 701-97-3, Safety of 3-Cyclohexylpropionic Acid.

Synthesis of novel benzothiozole and benzisoxazole functionalized unsymmetrical alkanes and study of their antimicrobial activity

Novel unsymmetrical alkanes 4 and 5 have been independently synthesized in single pot from 2-amino 5 / 6-hydroxybenzothiazole, 6-hydroxy-3-methyl-1,2-benzisoxazole and different dihaloalkanes [X-(CH2)(n)-X]. The compounds 4 and 5 have been screened for antimicrobial activity and some of them have-been found to show promising activity.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of 701-97-3, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 701-97-3, Name is 3-Cyclohexylpropionic Acid, SMILES is O=C(O)CCC1CCCCC1, belongs to benzisoxazole compound. In a article, author is Sreelaxmi, A, introduce new discover of the category.

Synthesis of 3-(1,2-benzisoxazole-3-yl) and 4-methyl-3-(1,2-benzisoxazole-3-yl)-1-benzopyran-2-ones and their florescence properties

The reaction of substituted 1,2-benzisoxazole-3-acetic acids (1) with 2-hydroxycarbonyl compounds (2) in the presence of acetic anhydride and triethyl amine yielded the title compound (7,8,9,10) in good yields. The fluorescence spectra of these compounds showed emission around 450 nm which has a very good optical brightening properties.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

701-97-3, Name is 3-Cyclohexylpropionic Acid, molecular formula is C9H16O2, Computed Properties of C9H16O2, belongs to Benzisoxazole compound, is a common compound. In a patnet, author is D’Anna, Francesca, once mentioned the new application about 701-97-3.

Kemp elimination: A probe reaction to study ionic liquids properties

The amino induced elimination of benzisoxazole into the relevant o-cyanophenolate ion (Kemp elimination) has been studied in [bmim][BF4] solution at 298 K. To have information about the interactions between reactants and ionic liquid, the reaction has been carried out at different temperatures (293-313 K). Several primary, secondary, and tertiary amines have been used to study the effect of amine structure on the reaction rate. The collected data show that the amine structure seems to have a crucial role in determining the reaction rate. Furthermore, as different cation or anion structures of an ionic liquid can significantly affect its properties, the title reaction has been performed in four different ionic liquids ([bmim][PF6], [bmim][NTf2], [bm(2)im][NTf2], and [bmpyrr][NTf2]), using pyrrolidine and piperidine as model amines. An H-donor negative solvent (MeOH and [bmim][NTf2]) effect on reaction rate was detected. Finally, a narrow range of activation parameters was calculated both for the reaction induced by different amines and for pyrrolidine and piperidine, in the presence of different ILs. This fact suggests the occurrence of an early transition state.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 701-97-3, Name is 3-Cyclohexylpropionic Acid, formurla is C9H16O2. In a document, author is Binet, Corinne, introducing its new discovery. Product Details of 701-97-3.

Benefit of liquid crystal moieties in the MIP technique

Several liquid crystalline imprinted materials have been synthesized from polysiloxanes or polyacrylates bearing mesogenic side-chains and low contents of cross-linkers. They were imprinted by various achiral or chiral templates, then tested for molecular recognition or assessed as specific catalysts. All mesogenic imprinted networks exhibit a much higher affinity towards the template than non-imprinted networks. On the other hand, the molecular trapping capacity was shown to be much greater than that of most of the previously studied non-mesomorphous systems. Moreover, it was shown that mesomorphic order provides significant enhancement to the bonding between the template and the liquid crystalline network and reinforces the shape memory of the imprinted cavities. Some of these materials were used to catalyze the isomerization of benzisoxazole. They exhibited an acceleration effect close to 100 between imprinted sites and non-imprinted ones. Lastly, cholesteric networks, that were imprinted by a chiral template, showed good properties for the enantiomer separation leading to an enantiomeric excess of 35% and a capacity of around 1 mmol g(-1). (C) 2007 Elsevier B.V. All rights reserved.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 701-97-3, Name is 3-Cyclohexylpropionic Acid, SMILES is O=C(O)CCC1CCCCC1, belongs to Benzisoxazole compound. In a document, author is Watson, TJ, introduce the new discover, Safety of 3-Cyclohexylpropionic Acid.

Process improvements for the preparation of kilo quantities of a series of isoindoline compounds

A series of isoindoline analogues with either an indazole (HMR 2934, HMR 2651) or benzisoxazole (HMR 2543) appendage were prepared for the proposed treatment of psychiatric disorders such as obsessive compulsive disorder and attention deficit disorder. The isoindoline compounds were prepared by reduction of the corresponding phthalimides with LiAlH4. One compound was not chiral, and the other two required an enantioselective synthesis. The key step for these optically active analogues involved the coupling by an S(N)2 process of either a piperazynyl intermediate or a piperdinyl intermediate with methyl 3-benzyloxy-2-trifluoromethansulfonatopropionate. The products for these two analogues had >98% ee. Process improvements led to the multi-kilogram syntheses of each of these compounds.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 701-97-3 is helpful to your research. Safety of 3-Cyclohexylpropionic Acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 701-97-3, Name is 3-Cyclohexylpropionic Acid, molecular formula is C9H16O2, belongs to Benzisoxazole compound. In a document, author is HAYAKAWA, T, introduce the new discover, Recommanded Product: 3-Cyclohexylpropionic Acid.

ZONISAMIDE REDUCES HYPOXIC-ISCHEMIC BRAIN-DAMAGE IN NEONATAL RATS IRRESPECTIVE OF ITS ANTICONVULSIVE EFFECT

The neuroprotective effect of a novel anticonvulsant, zonisamide, was investigated in neonatal rats with hypoxic-ischemic brain damage. Rats underwent left carotid ligation followed by hypoxic exposure (8% 0(2)) for 2.5 h. When zonisamide (75 mg/kg) was administered i.p. 1 h before hypoxia, it reduced the cortical infarction volume to 6 +/- 5% (mean +/- S.E.M.) from 68 +/- 7% in vehicle-treated controls and the striatal volume to 8 +/- 4% from 78 +/- 7%. Zonisamide also reduced neuronal necrosis in 5 hippocampal regions (the dentate gyrus, CA4, CA3, CA1, and the subiculum). The plasma zonisamide concentration before and after hypoxia was 47.9 +/- 2.0 mu g/ml and 42.3 +/- 3.9 mu g/ml, respectively. Epidural electrodes were implanted in 6 pups one day before hypoxia-ischemia. Electroencephalograms were recorded during hypoxia-ischemia in rats given zonisamide or vehicle before the insult. The intensity of seizure activities was similar in the zonisamide-treated pups and the vehicle-treated controls. These findings demonstrate that zonisamide reduces neonatal hypoxic-ischemic brain damage and that this protective effect does not depend on its anticonvulsant action.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 701-97-3. Recommanded Product: 3-Cyclohexylpropionic Acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of 701-97-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 701-97-3, Name is 3-Cyclohexylpropionic Acid, SMILES is O=C(O)CCC1CCCCC1, belongs to Benzisoxazole compound. In a article, author is Shastri, R. A., introduce new discover of the category.

Microwave induced synthesis of 3-substituted 1,2-benzisoxazole derivatives

A rapid, cost-effective and eco-friendly synthesis of 3-substituted 1,2-benzisoxazoles from o-hydroxy ketoximes in solvent free conditions using solid support under microwave irradiation has been achieved.

Synthetic Route of 701-97-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 701-97-3.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 701-97-3, Name is 3-Cyclohexylpropionic Acid, SMILES is O=C(O)CCC1CCCCC1, belongs to Benzisoxazole compound. In a document, author is Hoy, Sheridan M., introduce the new discover, Recommanded Product: 701-97-3.

Zonisamide: A Review of Its Use in the Management of Adults with Partial Seizures

Oral zonisamide (Zonegran (R)) is a benzisoxazole derivative chemically unrelated to other antiepileptic agents. It is indicated in the EU as monotherapy in the treatment of partial seizures, with or without secondary generalization, in adults with newly diagnosed epilepsy and as adjunctive therapy to other antiepileptic drugs (AEDs) in the treatment of adults with partial seizures, with or without secondary generalization. In a double-blind, multinational study in adults newly diagnosed with partial seizures, shorter-term monotherapy with once-daily zonisamide was noninferior to that with twice-daily carbamazepine controlled release in terms of seizure freedom according to the International League Against Epilepsy guidelines, with seizure freedom benefits maintained during longer-term therapy. In four randomized, double-blind, placebo-controlled studies in adults with refractory partial seizures, shorter-term adjunctive therapy with once-or twice-daily zonisamide reduced the frequency of seizures to a significantly greater extent than placebo, with antiepileptic efficacy sustained following longer-term treatment in this patient population. Zonisamide was generally well tolerated in adults with partial seizures participating in these studies, with the majority of adverse events being mild or moderate in severity. Thus, oral zonisamide as monotherapy or adjunctive therapy to other AEDs provides a useful option in the treatment of patients with partial seizures.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 701-97-3 is helpful to your research. Recommanded Product: 701-97-3.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry is an experimental science, Computed Properties of C9H16O2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 701-97-3, Name is 3-Cyclohexylpropionic Acid, molecular formula is C9H16O2, belongs to Benzisoxazole compound. In a document, author is Howe, NJ.

Synthesis of novel pyrazolobenzisoxazole ring systems via a 1,3-dipolar cycloaddition reaction

Compounds containing the novel 2H-pyrazolo[3,4-e] [1,2]benzisoxazole 2 and 4H-pyrazolo[4,3-g]-1,2-benzisoxazole 3 ring systems have been synthesized via a 1,3-dipolar cycloaddition reaction between acetonitrile oxide and the tetrahydroindazole.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 701-97-3. Computed Properties of C9H16O2.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics