Category: 929-59-9

Chemistry, like all the natural sciences, Computed Properties of C6H16N2O2, begins with the direct observation of nature¡ª in this case, of matter.929-59-9, Name is 1,2-Bis(2-aminoethoxy)ethane, SMILES is NCCOCCOCCN, belongs to Benzisoxazole compound. In a document, author is Albers, Lawrence James, introduce the new discover.

Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market?

Iloperidone is a new-generation atypical antipsychotic agent, acting as a serotonin/dopamine (5-HT2A/D-2) antagonist, under development by Vanda Pharmaceuticals for the treatment of schizophrenia, bipolar disorder and other psychiatric conditions. Chemically, iloperidone is a benzisoxazole, like risperidone, and shows a multiple receptor binding profile, sharing this feature with the other atypical antipsychotic agents. Administered orally, the drug is highly bound to plasma proteins and extensively metabolised. Several clinical trials have been carried out, to check efficacy, safety and side effects. in order to introduce iloperidone as an agent for the treatment of schizophrenia, a short overview of the disease and of the most important antipsychotic drugs available or under development will be reported. Iloperidone pharmacokinetics and pharmacodynamics are presented herein, together with an evaluation of clinical safety and efficacy results.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 929-59-9. Computed Properties of C6H16N2O2.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Sakuma, Shogo, once mentioned the application of 929-59-9, Name is 1,2-Bis(2-aminoethoxy)ethane, molecular formula is C6H16N2O2, molecular weight is 148.2034, MDL number is MFCD00040474, category is Benzisoxazole. Now introduce a scientific discovery about this category, Recommanded Product: 1,2-Bis(2-aminoethoxy)ethane.

Biological evaluation of novel benzisoxazole derivatives as PPAR delta agonists

We discovered novel peroxisome proliferator-activated receptor delta agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPAR delta transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte precursor cells in vitro. This indicates that this potential drug may be effective for the treatment of demyelinating disorders such as multiple sclerosis. (C) 2011 Elsevier Ltd. All rights reserved.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In an article, author is Serrano, Joao L., once mentioned the application of 929-59-9, Recommanded Product: 1,2-Bis(2-aminoethoxy)ethane, Name is 1,2-Bis(2-aminoethoxy)ethane, molecular formula is C6H16N2O2, molecular weight is 148.2034, MDL number is MFCD00040474, category is Benzisoxazole. Now introduce a scientific discovery about this category.

A synthetic route to novel 3-substituted-2,1-benzisoxazoles from 5-(2-nitrobenzylidene)(thio)barbiturates

2,1-Benzisoxazoles, also called anthranils, are one of the two types of aromatic bicyclic heterocycles having a benzene ring fused with an isoxazole, which are particularly recognized as valuable intermediates in organic synthesis. Nevertheless several methods can be found in the literature to prepare 2,1-benzisoxazoles, we herein report a new, efficient, simple, mild, and alternative procedure to prepare 3-substituted-2,1-benzisoxazoles from 5-(2-nitrobenzylidene)barbiturates in moderate to good yields (51-82%). All the novel benzisoxazoles showed spectral data fully consistent with the assigned structures, which were unequivocally confirmed by single crystal X-ray analysis. A possible mechanism of the reaction is proposed. In addition, a screening of the bioactivity of these benzisoxazoles as xanthine oxidase inhibitors, antioxidants, and cytotoxic compounds was performed. The benzisoxazole formed from barbituric acid revealed moderate xanthine oxidase inhibitory effects (IC50 = 22.10 mu M). (C) 2017 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 929-59-9, Name is 1,2-Bis(2-aminoethoxy)ethane, molecular formula is , belongs to Benzisoxazole compound. In a document, author is SATO, H, Computed Properties of C6H16N2O2.

STUDIES ON URICOSURIC DIURETICS .2. SUBSTITUTED 7,8-DIHYDROFURO[2,3-G]-1,2-BENZISOXAZOLE-7-CARBOXYLIC ACIDS AND 7,8-DIHYDROFURO[2,3-G]BENZOXAZOLE-7-CARBOXYLIC ACIDS

A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids 9 and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids 12 were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives 9 showed uricosuric and only weak diuretic activities, whereas the benzoxazoles 12 exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (9b, AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 929-59-9, in my other articles. Computed Properties of C6H16N2O2.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics