Awesome Chemistry Experiments For C7H6O3

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 99-06-9, Name is 3-Hydroxybenzoic acid, SMILES is O=C(O)C1=CC=CC(O)=C1, in an article , author is Yathirajan, HS, once mentioned of 99-06-9, HPLC of Formula: C7H6O3.

N-H+center dot center dot center dot Cl- and C-H center dot center dot center dot O interactions in 6-fluoro-3-(4-piperidinio)benz[d]isoxazole chloride

Supramolecular assembly of the title compound, C12H14ClFN2O, is primarily governed by N-H+…Cl- and C-H…O interactions, and a putative C-H…F interaction. The piperidine ring assumes a chair conformation, with the substituted benzisoxazole ring in an equatorial position.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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Chemistry is an experimental science, Name: 3-Hydroxybenzoic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 99-06-9, Name is 3-Hydroxybenzoic acid, molecular formula is C7H6O3, belongs to Benzisoxazole compound. In a document, author is Lalut, Julien.

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease

A rigidification strategy was applied to the preclinical candidate donecopride, an acetylcholinesterase inhibitor possessing 5-HT4R agonist activity. Inspired by promising bioactive benzisoxazole compounds, we have conducted a pharmacomodulation study to generate a novel series of multitarget directed ligands. The chemical synthesis of the ligand was optimized and compounds were evaluated in vitro against each target and in cellulo. Structure-activity relationship was supported by docking analysis in human acetylcholinesterase binding site. Among the synthesized compounds, we have identified a novel hybrid 32a (3-[2-[1-(cyclohexylmethyl)-4-piperidyl]ethyl]-4-methoxy-1,2-benzoxazole) able to display nanomolar acetylcholinesterase inhibitory effects and nanomolar Ki for 5-HT4R.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Soman, Shubhangi S., once mentioned the application of 99-06-9, Name is 3-Hydroxybenzoic acid, molecular formula is C7H6O3, molecular weight is 138.12, MDL number is MFCD00002506, category is Benzisoxazole. Now introduce a scientific discovery about this category, Application In Synthesis of 3-Hydroxybenzoic acid.

Synthesis of new naphthoisoxazole amide derivatives and study of their biological evaluations

A series of naphthoisoxazole amide derivatives 4a-h have been synthesized from naphthoisoxazole acetic acid 3. 2-Acetyl-1-naphthol-1 on reaction with pulverized sodium and diethyl carbonate gave 4-hydroxy naphthopyrone 2 which on Posner reaction gave naphthoisoxazole acetic acid 3. The cytotoxic activity study for inhibiting melanoma cell survival was evaluated on a series of melanoma cell lines. The anticonvulsant activity of these compounds has been evaluated in Wistar rats. A compound called 4h has been found to have anticonvulsant activity comparable to that of the standard drug phenytoin.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 99-06-9, Name is 3-Hydroxybenzoic acid, molecular formula is C7H6O3, belongs to Benzisoxazole compound. In a document, author is De Simone, G, introduce the new discover, Product Details of 99-06-9.

Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies

The antiepileptic drug zonisamide was considered to act as a weak inhibitor of the zinc enzyme carbonic anhydrase (CA, EC 4.2. 1.1) (with a K, of 4.3 mu M against the cytosolic isozyme 11). Here we prove that this is not true. Indeed, testing zonisamide in the classical assay conditions of the CO2 hydrase activity of hCA II, with incubation times of enzyme and inhibitor solution of 15 min, a K-1 of 10.3 mu M has been obtained. However, when the incubation between enzyme and inhibitor was prolonged to 1d h, the obtained K-1 was of 35.2 nM, of the same order of magnitude as that of the clinically used sulfonamides/sulfamates acetazolantide, methazolamide, ethoxzolamide and topiramate (K(1)s in the range of 5.4-15.4 nM). The inhibition of the human mitochondrial isozyme hCA V with these compounds has been also tested by means of a dansylamide competition binding assay, which showed zonisamide and topiramate to be effective inhibitors, with K(1)s in the range of 20.6-25.4 nM. The X-ray crystal structure of the adduct of hCA 11 with zonisamide has also been solved at a resolution of 1.70 A, showing that the sulfonamide moiety participates in the classical interactions with the Zn(II) ion and the residues Thr199 and Glu106, whereas the benzisoxazole ring, is oriented toward the hydrophobic half of the active site, establishing a large number of strong van der Waals interactions (< 4.5 A) with residues Gln92, Vall2l, Phe131, Leu198, Thr200, Pro202. (c) 2005 Elsevier Ltd. All rights reserved. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 99-06-9. Product Details of 99-06-9.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 99-06-9. COA of Formula: C7H6O3.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , COA of Formula: C7H6O3, 99-06-9, Name is 3-Hydroxybenzoic acid, molecular formula is C7H6O3, belongs to Benzisoxazole compound. In a document, author is Arndt, P, introduce the new discover.

Ring-enlargement and ring-opening reactions of benzoxazole, thiazoles, and benzisoxazole by zirconocene-alkyne complexes

Zirconocene alkyne complexes Cp(2)Zr(L)(Me(3)SiC(2)R) (L = Py, THF; R = SiMe(3), tBu) react with heterocyclic compounds like benzoxazole and related thiazoles to yield ring-expanded adducts Cp(2)Zr-C(SiMe(3))=C(R)-CH=N-o-C6H4-X (1-3) and Cp(2)Zr-C(SiMe(3))=C(SiMe(3))-CH=N-C(R’)=C(R’)-X (R’ = Me, H) (4, 5) by formal C-X (X = O, S) bond cleavage and coupling with the coordinated alkyne. In the case of benzisoxazole, the alkyne is not coupled but eliminated, and with ring-enlargement of the benzisoxazole a N-bridged dimer [Cp(2)Zr-N=CH-o-C6H4-O](2) (6) is formed. The obtained complexes 1, 3, and 6 were characterized by NMR spectra and crystal structure analysis.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Awesome and Easy Science Experiments about 3-Hydroxybenzoic acid

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Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 99-06-9, Name is 3-Hydroxybenzoic acid, SMILES is O=C(O)C1=CC=CC(O)=C1, in an article , author is Barmade, Mahesh A., once mentioned of 99-06-9, Recommanded Product: 3-Hydroxybenzoic acid.

Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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Chemistry is an experimental science, Product Details of 99-06-9, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 99-06-9, Name is 3-Hydroxybenzoic acid, molecular formula is C7H6O3, belongs to Benzisoxazole compound. In a document, author is Zareba, G.

Zonisamide: Review of its use in epilepsy therapy

Zonisamide is an antiepileptic drug used as adjunctive therapy for refractory partial seizures in adults. Because of the multiple mechanisms of action, it shows a broad spectrum of anticonvulsant activity and has been effective in several types of seizures, including partial and generalized seizures, tonic-clonic seizures and absence seizures in patients unresponsive to other anticonvulsants. Myoclonic epilepsy, Lennox-Gastaut syndrome and infantile spasms have also been treated effectively with zonisamide. Recent clinical studies have demonstrated additional potential for therapeutic use in neuropathic pain, bipolar disorder, migraine, obesity, eating disorders and Parkinson’s disease. Despite adverse events, zonisamide is relatively safe and well tolerated in patients, and shows low discontinuation rate. It has a good pharmacokinetic profile and a low drug interaction potential. Zonisamide is considered as a drug that effectively reduces the frequency of partial seizures. (C) 2005 Prous Science. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 99-06-9. Product Details of 99-06-9.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 99-06-9 is helpful to your research. Application In Synthesis of 3-Hydroxybenzoic acid.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 99-06-9, Name is 3-Hydroxybenzoic acid, SMILES is O=C(O)C1=CC=CC(O)=C1, belongs to Benzisoxazole compound. In a document, author is Younkin, Jason, introduce the new discover, Application In Synthesis of 3-Hydroxybenzoic acid.

Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists

Several pharmacophore models have been proposed for 5-HT2A serotonin receptor antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a given distance from each other, and from a basic amine. Although specified distances might vary, the models are relatively similar in their general construction. Because our preliminary data indicated that two aromatic (hydrophobic) moieties might not be required for such action, we deconstructed the serotonin-dopamine antipsychotic agent risperidone (1) into four smaller structural fragments that were thoroughly examined in 5-HT2A receptor binding and functional (i.e., two-electrode voltage clamp (TEVC) and intracellular calcium release) assays. It was apparent that truncated risperidone analogues behaved as antagonists. In particular, 6-fluoro-3-(1-methylpiperidin-4-yl)benzisoxazole (4) displayed high affinity for 5-HT2A, receptors (K-i, of ca. 12 nM) relative to risperidone (K-i of ca. 5 nM) and behaved as a potent 5-HT2A serotonin receptor antagonist. These results suggest that multiple aromatic (hydrophobic) moieties are not essential for high-affinity 5-HT2A receptor binding and antagonist activity and that current pharmacophore models for such agents are very much in need of revision.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is BALDAN, B, once mentioned the application of 99-06-9, Name is 3-Hydroxybenzoic acid, molecular formula is C7H6O3, molecular weight is 138.12, MDL number is MFCD00002506, category is Benzisoxazole. Now introduce a scientific discovery about this category, Product Details of 99-06-9.

A STAGE-SPECIFIC BLOCK IS PRODUCED IN CARROT SOMATIC EMBRYOS BY 1,2-BENZISOXAZOLE-3-ACETIC ACID

1,2-Benz-isoxazol-3-acetic acid is slightly toxic to unorganized growing carrot cells and completely prevents somatic embryogenesis beyond the globular stage. Its action is time dependent: if added early, it affects the determination of the early stages; if added later, after determination has occurred, it has practically no effect. The blocked forms can evolve, in the presence of the compound, creating secondary embryos that, in turn, are arrested at the globular stage. Since the secondary embryos adhere to the primary ones, irregular polyembryonic masses of typical appearance are created. The internal structures of the blocked globular embryos were examined and were shown to be enlarged, vacuolized and detached from the central cells. The protoderm also displayed an altered appearance. These data, when considered together with the effects of the compound on rooting and callus formation, suggest that benz-isoxazol acetic acid acts as a weak auxin.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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Reference of 99-06-9, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 99-06-9, Name is 3-Hydroxybenzoic acid, SMILES is O=C(O)C1=CC=CC(O)=C1, belongs to Benzisoxazole compound. In a article, author is YOSHII, K, introduce new discover of the category.

BETA-RIBONUCLEOSIDES AND ALPHA-ARABINONUCLEOSIDES CONTAINING THE 1,2-BENZISOXAZOLE AND 1,2-BENZISOTHIAZOLE RINGS

The reaction of the silylated base of 1,2-benzisoxazol-3(2H)-one (1) and its 7-methyl derivative 5 and 5-methyl-1,2-benzisothiazol-3(2H)-one (9), respectively, with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose followed by basic deprotection gave the corresponding beta-D-ribonucleosides, and the silylated base of 1, when treated with 1-O-acetyl-2,3,5-tri-O-benzoyl-alpha-D-arabinofuranose in the presence of stannic chloride, afforded the corresponding alpha-arabinonucleoside. Structural proofs of these nucleosides are provided from elemental analyses and H-1 and C-13 nmr spectra.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics