Category: Benzisoxazole

Neethu, K. S.; Sivaselvam, S.; Theetharappan, M.; Ranjitha, J.; Bhuvanesh, N. S. P.; Ponpandian, N.; Neelakantan, M. A.; Kaveri, M. V. published the article 《In vitro evaluations of biomolecular interactions, antioxidant and anticancer activities of Nickel(II) and Copper(II) complexes with 1:2 coordination of anthracenyl hydrazone ligands》. Keywords: anthracenyl hydrazone nickel copper complex preparation crystal mol structure; antioxidant anticancer nickel copper anthracenyl hydrazone complex; intercalation mol docking DNA nickel copper anthracenyl hydrazone complex.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Formula: C5H6N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

A set of nickel(II) and copper(II) complexes incorporated anthracenyl hydrazone ligands were synthesized and characterized with the help of various spectroscopic techniques. Single-crystal XRD studies revealed that all four complexes have square planar geometry in which the hydrazones are coordinated through NO atoms with 1:2 metal to ligand stoichiometry. Bio-mol. interactions of these complexes were analyzed using UV and emission spectroscopic studies, which revealed that compounds interact with calf thymus DNA (CT-DNA) through intercalation and also bind strongly with BSA. This further has been confirmed by theor. studies. Anticancer nature of the compounds was evaluated with the help of MTT assay against colon cancer cells (HCT-15) and normal skin cells (L929). It is verified that the complexes showed excellent cytotoxicity to cancer cells whereas negligible toxicity towards normal cells. Antioxidant activity was checked by DPPH radical scavenging assay and found that the complexes are capable of reducing available radicals. The complexes initiated cell death via reactive oxygen species generation was determined by ROS assay. The morphol. transformations observed in cell lines treated with different concentrations of complexes have been observed with the help of SEM (SEM). Flow cytometric anal. expressed that the synthesized complexes can induce apoptotic cell death, hence eligible for further studies.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Caramel products of glucose with water during heating process and their bioactivities.Category: benzisoxazole.

In this study, the type I caramel reactions of the glucose-water system were carried out. The glucose caramel products (GCPs) at different reaction stages were collected and the reaction rate, UV absorption, flavor compound, and the antioxidant and antibacterial activities were determined The result showed that the glucose reaction rate of the GCP yielded at 180°C and 4 min arrived at the stable range of around 80.0%. For UV absorptions of GCPs at 305 nm increased approx. in the exponential order. Moreover, the GCP yielded at 180°C and 4 min was revealed to have the highest concentration of main flavor compounds and potent antioxidant and antibacterial activities.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Bulky diarylammonium arenesulfonates as mild and extremely active dehydrative ester condensation catalysts, the main research direction is ester preparation; arenesulfonate diarylammonium bulky preparation dehydrative ester condensation catalyst; carboxylic acid esterification alc diarylammonium arenesulfonate catalyst.SDS of cas: 37443-42-8.

Bulky diarylammonium pentafluorobenzenesulfonates and tosylates serve as extremely active dehydration catalysts for the ester condensation reaction of carboxylic acids with equimolar amounts of sterically demanding alcs. and acid-sensitive alcs. Typically, the esterification reaction is performed in heptane by heating at 80 °C in the presence of 1 mol% of the catalyst without removing water. Esterification with primary alcs. proceeds without solvents even at room temperature Furthermore, 4-(N-mesitylamino)polystyrene resin-bound pentafluorobenzenesulfonate can be recycled more than 10 times without a loss of activity.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Electric Literature of C5H6N2O2.Goergen, Christina; Boden, Katharina; Reiss, Guido J.; Frank, Walter; Mueller, Thomas J. J. published the article 《One-pot activation-alkynylation-cyclization synthesis of 1,5-diacyl-5-hydroxypyrazolines in a consecutive three-component fashion》 about this compound( cas:3326-71-4 ) in Beilstein Journal of Organic Chemistry. Keywords: diacyl hydroxypyrazoline preparation; hetero aryl glyoxylic acid arylacetylene hydrazide activation alkynylation cyclization; C–C coupling; activation; alkynylation; copper; cyclization; multicomponent reactions. Let’s learn more about this compound (cas:3326-71-4).

A consecutive three-component activation-alkynylation-cyclization reaction of (hetero)aryl glyoxylic acids, oxalyl chloride, arylacetylenes, and hydrazides efficiently forms 1,5-diacyl-5-hydroxypyrazolines in moderate to good yields. The structures were unambiguously corroborated by comprehensive NMR spectroscopy and X-ray structure analyses of selected derivatives

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Application of 610-09-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Hydrolysis and interactions of D-cellobiose with polycarboxylic acids. Author is Amarasekara, Ananda S.; Wiredu, Bernard; Lawrence, Yen Maroney.

The hydrolysis of cellulose model compound D-cellobiose was studied with a series of eight common polycarboxylic acids and two monocarboxylic acids in aqueous medium using 0.500 mmol -COOH/L at 170 °C. The maleic acid showed the highest catalytic activity with turnover frequency (TOF) of 29.5 h-1. The interaction of carboxylic acids with D-cellobiose in DMSO-d6 was studied by determination of the pseudo first-order rate constant kH of anomeric -OH exchange rate in cellobiose using 1H NMR spectroscopy. The maleic, oxalic and citric acids showed infinitely large kH values indicating very strong interactions with D-cellobiose. The next highest interactions were found with phthalic acid (kH = 248.8 Hz). The FT-IR studies showed significant carboxylic acid C=O stretching frequency shifts (ΔνC=O) of 12, 13 and 10 cm-1 for maleic, oxalic and acetic acids resp. in mixtures with D-cellobiose.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Wang, Ling; Wan, Chao; Wang, Hongqin; Chen, Hongtao; Zhu, XiaoMeng; Li, Mingyu published an article about the compound: cis-Cyclohexane-1,2-dicarboxylic acid( cas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O ).Name: cis-Cyclohexane-1,2-dicarboxylic acid. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:610-09-3) through the article.

To improve the elec. conductivity of the dicyandiamide-cured elec. conductive adhesives (ECAs), short-chain difunctional acids with various structures including oxalic acid, succinic acid, adipic acid, phthalic acid and cis-hexahydrophthalic acid were introduced in-situ to replace the commonly used surfactant-stearic acid on the silver filler surface. Oxalic acid, phthalic acid and cis-hexahydrophthalic acid deteriorated the elec. conductivity of ECAs whereas the elec. conductivity was improved significantly with the addition of succinic acid and adipic acid. Moreover, the storage performance, viscosity, curing behavior, bulk resistivity and the shear strength of ECAs with varied content of adipic acid had been further studied. With the increment of adipic acid, the curing temperature of ECAs decreased, while the reaction between dicyandiamide and adipic acid happened as the content reached 0.3 wt%. And the adipic acid not just improved the elec. conductive, but also improved the shear strength without adversely affected the storage performance of ECAs. As the content of adipic acid reached 0.3 wt%, the lowest bulk resistivity 3.8×10-4 Ω cm was obtained, at the content of 0.5 wt%, the shear strength was improved to 18.5 MPa.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Morawetz, Herbert; Choi, Ling Siu published an article about the compound: cis-Cyclohexane-1,2-dicarboxylic acid( cas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O ).Quality Control of cis-Cyclohexane-1,2-dicarboxylic acid. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:610-09-3) through the article.

Succinic acid and substituted succinic acids undergo conformational transitions during ionization, and these are expected to affect their ionization equilibrium The 1H NMR data on the dependence of the conformational equilibrium of succinic acid and meso-2,3-dimethylsuccinic acid on their degree of ionization are interpreted in terms of the ratio of the 2nd ionization constants of the gauche and trans isomer, K2g/K2t, and the equilibrium constant Kc for the gauche-trans transition of the unionized acid. The K2g/K2t ratios obtained for the 2 above acids are compared with theratio of the 2nd ionization constants of cis- and trans-cyclohexane-1,2-dicarboxylic acids used as model compounds in which the carboxyls are gauche and trans to each other.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Cannizzaro reaction of aldehydes in TMAH thermochemolysis》. Authors are Tanczos, I.; Schoeflinger, M.; Schmidt, H.; Balla, J..The article about the compound:Methyl tetrahydrofuran-2-carboxylatecas:37443-42-8,SMILESS:O=C(C1OCCC1)OC).Quality Control of Methyl tetrahydrofuran-2-carboxylate. Through the article, more information about this compound (cas:37443-42-8) is conveyed.

Recently, tetramethylammonium hydroxide (TMAH) was advantageously used in the anal. pyrolysis of polymers, but yielded a great amount of carboxylic acid Me esters which were absent in conventional pyrolysis. The experiments with model compounds such as furaldehyde, benzaldehyde, hydroxy-, methoxy-, dimethoxybenzaldehyde and vanillin show that TMAH can react not only as a methylating and/or hydrolyzing agent but also with aldehydes according to a Cannizzaro reaction and the reaction products can be in-situ methylated to the corresponding esters and ethers.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

SDS of cas: 3326-71-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Solid-phase synthesis of hybrid 2,5-diketopiperazines using acylhydrazide, carbazate, semicarbazide, amino acid, and primary amine submonomers. Author is Rahim, Abdur; Sahariah, Biswajit; Baruah, Kalpita; Deka, Jugal Kishore Rai; Sarma, Bani Kanta.

46We report the solid-phase synthesis of N,N’-di(acylamino)-2,5-diketopiperazine, an acylhydrazide-based conformationally rigid 2,5-DKP scaffold having exocyclic N-N bonds. We also show that different combinations of acylhydrazides, carbazates, semicarbazides, amino acids, and primary amines can be used to synthesize a highly diverse collection of hybrid DKP mols. via the solid-phase submonomer synthesis route. Finally, we show incorporation of a Me substituent in one of the carbon atoms of the DKP ring to generate chiral daa- and hybrid-DKPs without compromising the synthetic efficiency.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The heats of hydration and energy contents of cis- and trans-cyclohexane-1,2-dicarboxylic acids, and their primary ions》. Authors are Wassermann, Albert.The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Reference of cis-Cyclohexane-1,2-dicarboxylic acid. Through the article, more information about this compound (cas:610-09-3) is conveyed.

The following values were obtained for the cis- and trans-cyclohexane-1,2-dicarboxylic acids and their ions, resp.: heat of combustion, kg.-cal./mole (constant temperature) 931.9, 929.5; heat of solution + first heat of ionization, -7.49, -6.48; energy content of primary anion in dilute solution, kg.-cal./mole 939.4, 936.0; mol. volume at 0° 126.5, 120.4; second heat of ionization +0.30, +0.24. The first ionization constant of the cis acid increases with rise in temperature, while that of the trans decreases. This leads to the conclusion that the trans ion is more hydrated than the cis ion, although the heat of hydration of the undissociated cis is not measurably greater than that of the trans acid.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics