Category: Benzisoxazole

Uno, Hitoshi; Kurokawa, Mikio published their research in Chemical & Pharmaceutical Bulletin on February 28 ,1978. The article was titled 《Studies on 3-substituted 1,2-benzisoxazole derivatives. IV. Rearrangement of N-substituted 2H-1,2-benzisoxazolin-3-one to 2-substituted 2H-1,3-benzoxazin-4-one》.Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one The article contains the following contents:

The base catalyzed ring expansion of 2-substituted 2H-1,2-benzisoxazolin-3-ones I (R = Ph, CO2Me, COPh, COMe, CCH, R1 = H; R = R1 = Ph; R = CO2Et, R1 = Me) to 2-substituted 2H-1,3-benzoxazin-4-ones II occurred during the alkylation of hydroxy-1,2-benzisoxazole. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In 1980,Acta Poloniae Pharmaceutica included an article by Domagalina, Eugenia; Gaj, Barbara; Slawik, Tomasz. Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one. The article was titled 《Arylsulfonyl and sulfanilyl derivatives of benzoxazoles and benzisoxazoles》. The information in the text is summarized as follows:

Benzoxazoles I (R = Cl, Br, R1 = H; R = H, R1 = Cl, Br, SO2NH2; R = Cl, Br, R1 = SO2NH2) and benzisoxazoles II (R = H, Cl, Br, SO2NH2) were prepared in 33-74% yields by treating 2-benzoxazolinones or 3-hydroxybenzisoxazoles, resp., with 4-AcNHC6H4SO2Cl in dioxane containing some Et3N. Similarly, 5-, 6-, and 7-amino-2-benzoxazolinone yielded III. I and III were deacetylated with HCl-EtOH; under similar conditions II yielded sulfanilic acid and the starting benzisoxazole derivative After reading the article, we found that the author used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-oneThe benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Ferraris, Dana; Duvall, Bridget; Ko, Yao-Sen; Thomas, Ajit G.; Rojas, Camilo; Majer, Pavel; Hashimoto, Kenji; Tsukamoto, Takashi published an article in Journal of Medicinal Chemistry. The title of the article was 《Synthesis and Biological Evaluation of D-Amino Acid Oxidase Inhibitors》.Application of 65685-50-9 The author mentioned the following in the article:

D-Amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids including D-serine, a full agonist at the glycine site of the NMDA receptor. A series of benzo[d]isoxazol-3-ol derivatives were synthesized and evaluated as DAAO inhibitors. Among them, 6-chlorobenzo[d]isoxazol-3-ol (CBIO) potently inhibited DAAO with an IC50 in the submicromolar range. Oral administration of CBIO in conjunction with D-serine enhanced the plasma and brain levels of D-serine in rats compared to the oral administration of D-serine alone. In the experiment, the researchers used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Application of 65685-50-9)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. Application of 65685-50-9 The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The author of 《Central effects of some new derivatives of benzoxazolin-2-one and 3-hydroxybenzisoxazole》 were Kolasa, Krystyna. And the article was published in Acta Poloniae Pharmaceutica in 1979. Recommanded Product: 65685-50-9 The author mentioned the following in the article:

The title compounds I (R = H or Br; R1 = H, Ac, or CO2Et), II (R = H or Br)and III (R = H or Br) tested in mice at their 1/5, 1/10, 1/20, and 1/40 LD50 dose showed a weak myorelaxant effect and weak inhibitory activity on the central nervous system. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Recommanded Product: 65685-50-9)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.Recommanded Product: 65685-50-9

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Wrubel, Juergen published an article on January 31 ,1980. The article was titled 《2-Substituted 5-amino-1,2-benzisoxazoles》, and you may find the article in Zeitschrift fuer Chemie.SDS of cas: 65685-50-9 The information in the text is summarized as follows:

Nitration of benzisoxazoles I (R = OH, Cl; R1 = H) gave I (R = OH, Cl; R1 = NO2), and reaction with Br or SO2Cl2 gave I (R = OH, Cl; R1 = Br, Cl). Reduction of I (R = OH, R1 = NO2) with SnCl2 gave I (R = OH, R1 = NH2), which was diazotized and coupled with aromatic amines or phenols to give the azo dyes I (R = OH, R4 = 4-Me2NC6H4N:N, 2-hydroxy-1-naphthylazo). After reading the article, we found that the author used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9SDS of cas: 65685-50-9)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.SDS of cas: 65685-50-9The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The author of 《2-Alkylaminomethylbenzisoxazolin-3-ones》 were Bien, Irena; Domagalina, Eugenia. And the article was published in Acta Poloniae Pharmaceutica in 1981. Application of 65685-50-9 The author mentioned the following in the article:

3-Hydroxybenzisoxazole and its halo substituted derivatives were converted in the Mannich reaction into 16 new I (R = H, Cl, Br, R1 = H; R = H, R1 = 6-Cl, 6-R; R = Br, R1 = 7-Br; R2 = 4-morpholinyl, 1-piperidinyl, 4-methyl-1-piperazinyl). A similar reaction with piperazine gave 6 II; analogous compounds were obtained from 2,5-dimethylpiperazine. The yields varied from 41-90% for I almost quant. for II. In tests against Trichomonas vaginalis, I (R = Cl, R1 = H, R2 = 4-morpholinyl) revealed activity higher than that of metronidazole and tinidazole; it was also active against Rhabdilis strongyloides. In the experiment, the researchers used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Application of 65685-50-9)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.Application of 65685-50-9The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In 2002,Science of Synthesis included an article by Smalley, R. K.. HPLC of Formula: 65685-50-9. The article was titled 《Product class 10: 1,2-benzisoxazoles and related compounds》. The information in the text is summarized as follows:

A review presents various methods of ring-closure reaction and substituent modification for the synthesis of 1,2-benzisoxazoles and related compounds In the experiment, the researchers used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9HPLC of Formula: 65685-50-9)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.HPLC of Formula: 65685-50-9

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Slawik, T.; Skibinski, R.; Paw, B.; Dzialo, G. published an article in Acta Chromatographica. The title of the article was 《Reversed-phase TLC study of the lipophilicity of some 3-hydroxy-1,2-Benzisoxazoles substituted in the benzene ring》.Reference of 5-Bromobenzo[d]isoxazol-3(2H)-one The author mentioned the following in the article:

The relative lipophilicity, RM0, and specific hydrophobic surface area of eleven 3-hydroxy-1,2-benzoisoxazoles substituted in the benzene ring (two isomeric fluoro, three isomeric chloro, three isomeric bromo and dibromo derivatives, and a nitro derivative) have been studied by reversed-phase thin layer chromatog. (RP-TLC) on silica gel RP-C18 plates with methanol-water mixtures as mobile phases. Linear correlation between the volume fraction of methanol and RM values a limited range was established with high correlation coefficients (r > 0.99). Lipophilicity RM0 was compared with computed partition coefficients IAlogP, AlogPs, clogP, milogP, logPKOWIN and xlogP. The best correlation (r > 0.9) was found between RM0 and logPKOWIN anx xlogP values. Principal-components anal. (PCA) was also used to compare RM0 values with computed partition coefficients. The chromatog. behavior of 3-hydroxy-1,2-benzisoxazoles was compared with that of their bioisosteric analogs 1,2-benzisothiazolonoles. Exptl. RM0 values for both groups of compounds were in accordance with the equation RM0 = aRM0 + b (r > 0.9). In the experimental materials used by the author, we found 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Reference of 5-Bromobenzo[d]isoxazol-3(2H)-one)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. Reference of 5-Bromobenzo[d]isoxazol-3(2H)-one The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics