Category: Benzisoxazole

Gao, Lanchang; Yang, Zhengge; Xiong, Jiaying; Hao, Chao; Ma, Ru; Liu, Xin; Liu, Bi-Feng; Jin, Jian; Zhang, Guisen; Chen, Yin published the artcile< Design, synthesis and biological investigation of flavone derivatives as potential multi-receptor atypical antipsychotics>, HPLC of Formula: 84163-77-9, the main research area is flavone preparation antipsychotic dopamine serotonin receptor; atypical antipsychotics; dopamine; multi-target; serotonin.

The design of a series of novel flavone derivatives I (X = N, CH; Ar = 2-methoxyphenyl, 6-fluorobenzo[d]isoxazol-3-yl, pyrimidin-2-yl, etc.; n = 1, 2), II (m = 1, 2) and III (R1 = H, Cl; R2 = H, Me) was synthesized as potential broad-spectrum antipsychotics by using multi-receptor affinity strategy between dopamine receptors and serotonin receptors. Among them, I (X = CH, Ar = 6-fluorobenzo[d]isoxazol-3-yl, n = 2), (IV) exhibited a promising preclin. profile. Compound IV not only showed high affinity for dopamine D2, D3, and serotonin 5-HT1A, 5-HT2A receptors, but was also endowed with low to moderate activities on 5-HT2C, α1, and H1 receptors, indicating a low liability to induce side effects such as weight gain, orthostatic hypotension and QT prolongation. In vivo behavioral studies suggested that compound IV has favorable effects in alleviating the schizophrenia-like symptoms without causing catalepsy. Taken together, compound V has the potential to be further developed as a novel atypical antipsychotic.

Moleculespublished new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, HPLC of Formula: 84163-77-9.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Paul, Anirudra; Seidel, Daniel published the artcile< α-Functionalization of Cyclic Secondary Amines: Lewis Acid Promoted Addition of Organometallics to Transient Imines>, Reference of 84163-77-9, the main research area is cyclic secondary amine alpha functionalization Lewis acid organometallic imine.

Cyclic imines, generated in situ from their corresponding N-lithiated amines and a ketone hydride acceptor, undergo reactions with a range of organometallic nucleophiles to generate α-functionalized amines in a single operation. Activation of the transient imines by Lewis acids that are compatible with the presence of lithium alkoxides is crucial to accommodate a broad range of nucleophiles including lithium acetylides, Grignard reagents, and aryllithiums with attenuated reactivities.

Journal of the American Chemical Societypublished new progress about Alkali metal alkoxides, lithium alkoxides Role: RGT (Reagent), RACT (Reactant or Reagent). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Reference of 84163-77-9.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Wang, Jin-Lin; Liu, Mei-Ling; Zou, Jian-Yu; Sun, Wen-Hui; Liu, Xue-Yuan published the artcile< Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration>, Name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, the main research area is amino amide preparation; alkene hydroxylamine copper catalyst aminoarylation.

A new strategy for aminoarylation of alkenes by copper-catalyzed Smiles rearrangement using O-benzoylhydroxylamines as the amine reagent was described.. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition.

Organic Letterspublished new progress about Amino amides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Zhang, Ze-Xin; Willis, Michael C. published the artcile< Sulfondiimidamides as new functional groups for synthetic and medicinal chemistry>, Reference of 84163-77-9, the main research area is sulfondiimidamide preparation.

Due to their three-dimensional structure, chem. and metabolic stability, polarity, and hydrogen-bonding ability, sulfonamides RS(=NC(CH3)2CH2(CH3)3)(=NNs)R1 (R1 = Et, 4-fluorophenyl, cyclopropyl, pyridin-3-yl, etc. ;NH2, 2-methylpropan-2-aminyl, morpholin-4-yl) occupy a privileged position among the functional groups used to design bioactive mols. The mono aza variants, sulfonimidamides, a functional group known since the 1930s, possess an extra nitrogen atom, which delivers an addnl. point of diversity and introduces chirality at sulfur. The sulfondiimidamides are viable mols. and by using an unsym. sulfurdiimide as a linchpin, in combination with organometallic reagents RMgX (X = Br, Cl) and amines R1NH, their three-component assembly is showed. Variation of the substrates, and the controlled manipulation of nitrogen functionality, allows a broad range of substituents to be introduced at all three nitrogen atoms and at carbon.

Chempublished new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Reference of 84163-77-9.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Favalli, Nicholas; Bassi, Gabriele; Bianchi, Davide; Scheuermann, Jorg; Neri, Dario published the artcile< Large screening of DNA-compatible reaction conditions for Suzuki and Sonogashira cross-coupling reactions and for reverse amide bond formation>, Recommanded Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, the main research area is alkyne pinacol borane boronic acid DNA synthesis carboxylic acid; Suzuki Sonogashira cross coupling reverse amide formation DNA compatible; DNA-compatible reactions; DNA-encoded libraries; Reverse amide bond formation; Sonogashira cross-coupling; Suzuki cross-coupling.

Progress in DNA-encoded chem. library synthesis and screening crucially relies on the availability of DNA-compatible reactions, which proceed with high yields and excellent purity for a large number of possible building blocks. In the past, exptl. conditions have been presented for the execution of Suzuki and Sonogashira cross-coupling reactions on-DNA. In this article, our aim was to optimize Suzuki and Sonogashira reactions, comparing our results to previously published procedures. We have tested the performance of improved conditions using 606 building blocks (including boronic acids, pinacol boranes and terminal alkynes), achieving >70% conversion for 84% of the tested mols. Moreover, we describe efficient exptl. conditions for the on-DNA synthesis of amide bonds, starting from DNA derivatives carrying a carboxylic acid moiety and 300 primary, secondary and aromatic amines, as amide bonds are frequently found in DNA-encoded chem. libraries thanks to their excellent DNA compatibility.

Bioorganic & Medicinal Chemistrypublished new progress about Boronic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Recommanded Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis new hetrocyclic compounds derived from fouroic acid.Recommanded Product: 2-Furoic hydrazide.

The preparation of new comounds starting from acid (furoic). The acid was converted to five membered ring (oxadiazole). The acid was reacted with ethanol in presence of sulfuric acid then converted to hydrazide compound by reacting it with hydrazine hydrate. The hydrazide also reacted with CS2 carbon disulfide to obtain oxadiazole ring. Then the oxadiazole ring reacted with hydrazine hydrate to give hydrazino oxadiazole. Derivativies of oxadiazole obtained from the reaction of different aldehydes with hydrazine oxadiazole to have Schiff’s bases and the diazonium salts was prepared from the reaction of hydrazino oxadiazole with derivatives of phenols then the (OH)group of phenols was reacted with acid chloride to obtain ester compounds The prepared compounds were characterized by FT-IR, 1H-NMR spectra and the m.ps. were recorded and the purity was checked besides the biol. activity was evaluated.

After consulting a lot of data, we found that this compound(3326-71-4)Recommanded Product: 2-Furoic hydrazide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Quality Control of 2-Furoic hydrazide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors.

Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacol. profile, and mol. modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kα dual inhibitors. The surprising selectivity for PI3Kα may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kα show potential for the treatment of cancer.

After consulting a lot of data, we found that this compound(3326-71-4)Quality Control of 2-Furoic hydrazide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Coordination preference of 1,2-bis((1H-imidazole-1-yl)methyl)benzene and different carboxylate ligands with transition metal ions directed by weak interactions, the main research direction is copper cadmium silver imidazoleylmethylbenzene hydroxybenzoate cyclohexenecarboxylate cyclohexanecarboxylate polymer preparation; thermal stability luminescence transition metal imidazoleylmethylbenzene hydroxybenzoate cyclohexenecarboxylate cyclohexanecarboxylate; crystal structure transition metal imidazoleylmethylbenzene hydroxybenzoate cyclohexenecarboxylate cyclohexanecarboxylate.Formula: C8H12O4.

Three novel metal-organic complexes, formulated as [Cu2(2-HBA)2(bimb)4] (1), {[Cd(CEDA)(bimb)]·H2O}n (2), and {[Ag2(bimb)2]·(1,4-CDA)·13H2O} (3) (bimb = 1,2-bis((1H-imidazole-1-yl)methyl)benzene; 2-HBA = 2-hydroxybenzoic acid; CEDA = cyclohex-4-ene-1,2-dicarboxylic acid; 1,4-CDA = cyclohexane-1,4-dicarboxylic acid), were synthesized by self-assembly of mixed ligands with Cu(II), Cd(II), and Ag(I) under hydrothermal conditions and characterized by means of single-crystal X-ray diffraction, X-ray powder diffraction, IR spectra, thermogravimetric anal., fluorescence spectra and UV-vis absorption spectra. 1 Is shown as a 0D structure, which is formed by Cu2+, 2-HBA ligands and bimb ligands. 2 Displays a 1D ladder structure, which is built by Cd2+, CEDA ligands and bimb ligands, and it is assembled into 2D structure by hydrogen bonding. 3 Possesses a 0D [Ag(bimb)]2 dimer which is assembled into 3D structure by the Ag-O weak interaction and hydrogen bonding. Interestingly, a rare 13-core water cluster participates in forming the network of 3. The UV-vis spectrum and luminescence properties were also studied and discussed.

After consulting a lot of data, we found that this compound(610-09-3)Formula: C8H12O4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles, published in 2019, which mentions a compound: 3326-71-4, mainly applied to DMF aryl hydrazide copper catalyst oxidative heterocyclization green chem; aryl oxadiazole preparation oxygen copper catalyst oxidation green chem; oxadiazolone aryl preparation, Product Details of 3326-71-4.

An unprecedented Cu-catalyzed direct annulation of hydrazides with N,N-dimethylformamide (DMF) was developed, providing an efficient synthesis of valuable 1,3,4-oxadiazoles. This process featured short reaction time and safely conducted on gram scale. The reaction also facilitated the convenient synthesis of 1,3,4-oxadiazole-2(3H)-ones. Moreover, the mechanistic studies suggested that the source of CH was from the N-Me group of DMF.

The article 《DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles》 also mentions many details about this compound(3326-71-4)Product Details of 3326-71-4, you can pay attention to it, because details determine success or failure

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Evaluation of the anticorrosivity by low-energy photoelectron emission of the magnetic metal particles for magnetic recording media.Application In Synthesis of cis-Cyclohexane-1,2-dicarboxylic acid.

The correlation between the anticorrosivity and the intensity of the low-energy photoelectron emission of Fe particles for magnetic recording was studied. Particles with higher anticorrosivity showed lower emission intensity. Particles treated with cis-1,2-cyclohexyldicarboxylic acid showed a higher emission threshold. This higher threshold was explained by the formation of a surface potential barrier on the outer layer of γ-Fe2O3 by anionic species.

The article 《Evaluation of the anticorrosivity by low-energy photoelectron emission of the magnetic metal particles for magnetic recording media》 also mentions many details about this compound(610-09-3)Application In Synthesis of cis-Cyclohexane-1,2-dicarboxylic acid, you can pay attention to it, because details determine success or failure

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics