Continuously updated synthesis method about 37443-42-8

This literature about this compound(37443-42-8)Synthetic Route of C6H10O3has given us a lot of inspiration, and I hope that the research on this compound(Methyl tetrahydrofuran-2-carboxylate) can be further advanced. Maybe we can get more compounds in a similar way.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 37443-42-8, is researched, Molecular C6H10O3, about Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists, the main research direction is tetrahydrofuroyl phenylalanine preparation VLA4 antagonist.Synthetic Route of C6H10O3.

A series of substituted tetrahydrofuroyl-1-phenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. Substitution of the α carbon of the THF with aryl groups increased the specificity for VLA-4 vs. α4β7 while amide substitution increased the potency of the series without increasing the specificity. Substitution of the β carbon of the THF with keto or amino groups slightly improved the specificity for VLA-4 vs. α4β7 but with a significant loss in binding affinity for VLA-4.

This literature about this compound(37443-42-8)Synthetic Route of C6H10O3has given us a lot of inspiration, and I hope that the research on this compound(Methyl tetrahydrofuran-2-carboxylate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics