o-Iodoxy benzoic acid-mediated synthesis of 3,5-diarylisoxazoles and isoxazole-3-carboxylic acids was written by Desai, Vidya G.;Naik, Sneha R.;Dhumaskar, Kashinath L.. And the article was included in Synthetic Communications in 2014.Category: benzisoxazole This article mentions the following:
A new, convenient, eco-friendly synthesis of 3,5-diarylisoxazoles is reported from α,β-unsaturated ketoximes. Similarly, a novel synthesis of isoxazolecarboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic 2-iodoxybenzoic acid (IBX) as an oxidative cyclization reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodol. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4Category: benzisoxazole).
5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazole is an aromatic organic compound containing a benzene-fused isoxazole ring structure. It has reactive sites which allow for functionalization. The benzisoxazole scaffold and its analogues can be found in biologically active compounds across a number of different therapeutic areas as anti-HIV,antimicrobial, antipsychotic, anti-inflammatory, analgesic, and so on.Category: benzisoxazole
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics