The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ) is researched.Application In Synthesis of Methyl tetrahydrofuran-2-carboxylate.Mendes da Silva, Joaquim Fernando; Walters, Marcus; Al-Damluji, Saad; Ganellin, C. Robin published the article 《Molecular features of the prazosin molecule required for activation of Transport-P》 about this compound( cas:37443-42-8 ) in Bioorganic & Medicinal Chemistry. Keywords: prazosin analog preparation activation Transport P amine. Let’s learn more about this compound (cas:37443-42-8).
Closely related structural analogs of prazosin have been synthesized and tested for inhibition and activation of Transport-P in order to identify the structural features of the prazosin mol. that appear to be necessary for activation of Transport-P. So far, all the compounds tested are less active than prazosin. It is shown that the structure of prazosin appears to be very specific for the activation. Only quinazolines have been found to activate, and the presence of the 6,7-dimethoxy and 4-amino groups appears to be critically important.
There is still a lot of research devoted to this compound(SMILES：O=C(C1OCCC1)OC)Application In Synthesis of Methyl tetrahydrofuran-2-carboxylate, and with the development of science, more effects of this compound(37443-42-8) can be discovered.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics