Discovery of 6-Methylbenzo[d]isoxazol-3(2H)-one

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C8H7NO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 66571-26-4, in my other articles.

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C8H7NO2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 66571-26-4, name is 6-Methylbenzo[d]isoxazol-3(2H)-one. In an article£¬Which mentioned a new discovery about 66571-26-4

Benzimidazolones: A new class of selective peroxisome proliferator- activated receptor gamma (PPARgamma) modulators

A series of benzimidazolone carboxylic acids and oxazolidinediones were designed and synthesized in search of selective PPARgamma modulators (SPPARgammaMs) as potential therapeutic agents for the treatment of type II diabetes mellitus (T2DM) with improved safety profiles relative to rosiglitazone and pioglitazone, the currently marketed PPARgamma full agonist drugs. Structure-activity relationships of these potent and highly selective SPPARgammaMs were studied with a focus on their unique profiles as partial agonists or modulators. A variety of methods, such as X-ray crystallographic analysis, PPARgamma transactivation coactivator profiling, gene expression profiling, and mutagenesis studies, were employed to reveal the differential interactions of these new analogues with PPARgamma receptor in comparison to full agonists. In rodent models of T2DM, benzimidazolone analogues such as (5R)-5-(3-{[3-(5-methoxybenzisoxazol-3-yl)benzimidazol-1-yl]methyl}phenyl) -5-methylox-azolidinedione (51) demonstrated efficacy equivalent to that of rosiglitazone. Side effects, such as fluid retention and heart weight gain associated with PPARgamma full agonists, were diminished with 51 in comparison to rosiglitazone based on studies in two independent animal models. (Figure presented)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C8H7NO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 66571-26-4, in my other articles.

Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics