New Advances in Chemical Research in 2021. Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. 79-14-1, Name is 2-Hydroxyacetic acid, molecular formula is C2H4O3, COA of Formula: https://www.ambeed.com/products/79-14-1.html, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Basarab, Gregory S., once mentioned the new application about 79-14-1.
The compounds described herein with a spirocyclic architecture fused to a benzisoxazole ring represent a new class of antibacterial agents that operate by inhibition of DNA gyrase as corroborated in an enzyme assay and by the inhibition of precursor thymidine into DNA during cell growth. Activity resided in the configurationally lowest energy (2S,4R,4aR) diastereomer. Highly active compounds against Staphylococcus aureus had sufficiently high solubility, high plasma protein free fraction, and favorable pharmacokinetics to suggest that in vivo efficacy could be demonstrated, which was realized with compound (-)-1 in S. aureus mouse infection models. A high drug exposure NOEL on oral dosing in the rat suggested that a high therapeutic margin could be achieved. Importantly, (-)-1 was not cross-resistant with other DNA gyrase inhibitors such as fluoroquinolone and aminocoumarin antibacterials. Hence, this class shows considerable promise for the treatment of infections caused by multidrug resistant bacteria, including S. aureus.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 79-14-1, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/79-14-1.html.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics