#REF!
MOST EFFICIENT INTRAMOLECULAR GENERAL ACID CATALYSIS OF ACETAL HYDROLYSIS BY THE CARBOXY GROUP
The hydrolysis of 4-methoxymethoxybenzisoxazole-3-carboxylic acid (halflife 31 s at 39-degrees-C) is the fastest measured for a methoxymethyl acetal: catalysis by the neighbouring CO2H group is facilitated by a strong intramolecular hydrogen bond.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics