Computed Properties of C7H4BrNO2On October 31, 1978 ,《Acylation of benzoxazolin-2-ones and 3-hydroxy-1,2-benzisoxazoles》 appeared in Polish Journal of Pharmacology and Pharmacy. The author of the article were Domagalina, Eugenia; Slawik, Tomasz. The article conveys some information:
5-Bromo- and 5,7-dibromobenzoxazolin-2-ones were acylated with Ac2O, R1C6H4COCl (R1 = H, 2-Cl, 4-NO2), and R2O2CCl (R2 = Me, Et) to give primarily N-acylated products I (Brn = 5-Br, 5,7-Br2; R3 = Me, R1C6H4, R2O). The isomeric brominated 3-hydroxy-1,2-benzisoxazoles were predominantly O-acylated to give II (R3 the same as above). Exceptions were benzoxazole III and benzisoxazolinones IV (Brn = H, 5-Br, 5,7-Br2; R3 = R2O). IV (Brn = H, 5-Br; R3 = EtO) were the strongest central nervous system depressants and they also showed anticonvulsant activity. 5-Bromo-3-hydroxy-1,2-benzisoxazole and IV (Brn = H, R3 = EtO) had significant analgesic activity. In the experiment, the researchers used many compounds, for example, 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Computed Properties of C7H4BrNO2)
5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.Computed Properties of C7H4BrNO2
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics