With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.828300-70-5,Benzo[d]isoxazol-6-amine,as a common compound, the synthetic route is as follows.
A quantity of 0.13 g (1 mmole) OF BENZO [d] isoxazol-6-ylamine is treated with 0.27 g (1 mmole) of 6, 8-Dibromo-imidazo [1, 2-a] pyrazine in acetonitrile with 3 eq. OF K2C03 AT REFLUX for 16 hrs. The reaction mixture is cooled partitioned between ethyl acetate and water, the organic extracts are dried over anhydrous MGSO4 and evaporated in vacuo to afford Benzo [d] ISOXAZOL-6-YL- (6-BROMO- imidazo [1, 2-A] PYRAZIN-8-YL)-AMINE
As the paragraph descriping shows that 828300-70-5 is playing an increasingly important role.
Reference£º
Patent; CELLULAR GENOMICS, INC.; WO2005/5429; (2005); A1;,
Benzisoxazole – Wikipedia
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