Chemistry, like all the natural sciences, Safety of 1,2-Benzisoxazole-3-acetic Acid, begins with the direct observation of nature¡ª in this case, of matter. In a Article£¬Which mentioned a new discovery about 4865-84-3.
Facile preparation of protected benzylic and heteroarylmethyl amines via room temperature Curtius rearrangement
A step-wise, room temperature procedure for acyl azide formation and the subsequent Curtius rearrangement of phenyl and heteroaryl acetic acids is described. We have developed a protocol for room temperature Curtius rearrangement in MeOH or CHCl3 that provides an improvement over standard conditions, avoiding the use of additives or heat. This room temperature optimization of the Curtius rearrangement prevents the formation of side products often observed with benzylic acids, allowing access to a variety of benzylic and heteroarylmethyl amines.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of 1,2-Benzisoxazole-3-acetic Acid, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about Safety of 1,2-Benzisoxazole-3-acetic Acid
Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics