The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Electric Literature of C5H6N2O2.Goergen, Christina; Boden, Katharina; Reiss, Guido J.; Frank, Walter; Mueller, Thomas J. J. published the article 《One-pot activation-alkynylation-cyclization synthesis of 1,5-diacyl-5-hydroxypyrazolines in a consecutive three-component fashion》 about this compound( cas:3326-71-4 ) in Beilstein Journal of Organic Chemistry. Keywords: diacyl hydroxypyrazoline preparation; hetero aryl glyoxylic acid arylacetylene hydrazide activation alkynylation cyclization; C–C coupling; activation; alkynylation; copper; cyclization; multicomponent reactions. Let’s learn more about this compound (cas:3326-71-4).
A consecutive three-component activation-alkynylation-cyclization reaction of (hetero)aryl glyoxylic acids, oxalyl chloride, arylacetylenes, and hydrazides efficiently forms 1,5-diacyl-5-hydroxypyrazolines in moderate to good yields. The structures were unambiguously corroborated by comprehensive NMR spectroscopy and X-ray structure analyses of selected derivatives
After consulting a lot of data, we found that this compound(3326-71-4)Electric Literature of C5H6N2O2 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics