Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 629-25-4, Name is Sodium Laurate, molecular formula is C12H23NaO2, belongs to Benzisoxazole compound, is a common compound. In a patnet, author is Naidu, Kalaga Mahalakshmi, once mentioned the new application about 629-25-4, Safety of Sodium Laurate.
Design, synthesis and biological evaluation of 5-(2-(4-(substituted benzo[d]isoxazol-3-yl) piperazin-1-yl)acetyl)indolin-2-one and 5-(2-(4-substitutedpiperazin-1-yl)acetyl)indolin-2-one analogues as novel anti-tubercular agents
A series of thirty-six novel 5-(2-(4-(benzo[d]isoxazol-3-yl)piperazin-1-yl)acetyl)indolin-2one and 5-(2-(4-substitutedpiperazin-1-yl)acetyl)indolin-2-one analogues were synthesized, characterized and screened for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv strain. These compounds exhibited minimum inhibitory concentration between 1.56 and 50 mu g/mL. Among these derivatives, compounds 10c, 10d, 10j, 10o and 10v (MIC 6.25 mu g/mL) displayed moderate activity, while compounds 10e, 10l, 10q, 10w,10x, 12d, 12e and 12i (MIC 3.12 mu g/mL) showed good anti-tubercular activity and compounds 10f, 10k, 10p, 10r, 12f, 12j and 12k (MIC 1.56 mu g/mL) exhibited excellent anti-tubercular activity. In addition, MTT assay was accomplished on the active analogues of the series against mouse macrophage (RAW 264.7) cells to evaluate the cytotoxic effect of the newly synthesized compounds and selectivity index of the compounds was determined. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 629-25-4. The above is the message from the blog manager. Safety of Sodium Laurate.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics