In an article, author is Hasegawa, Daisuke, once mentioned the application of 6108-17-4, Name: Lithium acetate dihydrate, Name is Lithium acetate dihydrate, molecular formula is C2H7LiO4, molecular weight is 102.0156, MDL number is MFCD00066949, category is Benzisoxazole. Now introduce a scientific discovery about this category.
Pharmacokinetics and toxicity of zonisamide in cats
With the eventual goal of making zonisamide (ZNS), a relatively new antiepileptic drug, available for the treatment of epilepsy in cats, the pharmacokinetics after a single oral administration at 10 mg/kg and the toxicity after 9-week daily administration of 20 mg/kg/day of ZNS were Studied in healthy cats. Pharmacokinetic parameters obtained with a single administration of ZNS at 10 mg/day were as follows: C-max = 13.1 mu g/ml; T-max = 4.0 h; T-1/2 = 33.0 h; areas under the curves (AUCs) – 720.3 mu g/ml h (values represent the medians). The Study with daily administrations revealed that the toxicity of ZNS was comparatively low in cats, suggesting that it may be an available drug for cats. However, half of the cats that were administered 20 mg/kg/day daily showed adverse reactions Such as anorexia, diarrhoea, vomiting, somnolence and locomotor ataxia. (C) 2008 ESFM and AAFP. published by Elsevier Ltd. All rights reserved.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics