Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 546-89-4, Name is Lithiumacetate, SMILES is CC([O-])=O.[Li+], belongs to Benzisoxazole compound. In a document, author is Cullen, William, introduce the new discover, Quality Control of Lithiumacetate.
Highly efficient catalysis of the Kemp elimination in the cavity of a cubic coordination cage
The hollow cavities of coordination cages can provide an environment for enzyme-like catalytic reactions of small-molecule guests. Here, we report a new example (catalysis of the Kemp elimination reaction of benzisoxazole with hydroxide to form 2-cyanophenolate) in the cavity of a water-soluble M8L12 coordination cage, with two features of particular interest. First, the rate enhancement is among the largest observed to date: at pD 8.5, the value of k(cat)/k(uncat) is 2 x 10(5), due to the accumulation of a high concentration of partially desolvated hydroxide ions around the bound guest arising from ionpairing with the 16+ cage. Second, the catalysis is based on two orthogonal interactions: (1) hydrophobic binding of benzisoxazole in the cavity and (2) polar binding of hydroxide ions to sites on the cage surface, both of which were established by competition experiments.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 546-89-4 is helpful to your research. Quality Control of Lithiumacetate.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics