Related Products of 99822-23-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 99822-23-8, Name is 5-Fluorobenzo[d]isoxazol-3(2H)-one, molecular formula is C7H4FNO2, introducing its new discovery.
Discovery and lead optimisation of a potent, selective and orally bioavailable RARbeta agonist for the potential treatment of nerve injury
Oxadiazole replacement of an amide linkage in an RARalpha agonist template 1, followed by lead optimisation, has produced a highly potent and selective RARbeta agonist 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid (10) with good oral bioavailability in the rat and dog. This molecule increases neurite outgrowth in vitro and induces sensory axon regrowth in vivo in a rodent model of avulsion and crush injury, and thus has the potential for the treatment of nerve injury.
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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics