Ferraris, Dana; Duvall, Bridget; Ko, Yao-Sen; Thomas, Ajit G.; Rojas, Camilo; Majer, Pavel; Hashimoto, Kenji; Tsukamoto, Takashi published an article in Journal of Medicinal Chemistry. The title of the article was 《Synthesis and Biological Evaluation of D-Amino Acid Oxidase Inhibitors》.Application of 65685-50-9 The author mentioned the following in the article:
D-Amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids including D-serine, a full agonist at the glycine site of the NMDA receptor. A series of benzo[d]isoxazol-3-ol derivatives were synthesized and evaluated as DAAO inhibitors. Among them, 6-chlorobenzo[d]isoxazol-3-ol (CBIO) potently inhibited DAAO with an IC50 in the submicromolar range. Oral administration of CBIO in conjunction with D-serine enhanced the plasma and brain levels of D-serine in rats compared to the oral administration of D-serine alone. In the experiment, the researchers used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Application of 65685-50-9)
5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. Application of 65685-50-9 The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics