Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 719-64-2, Name is 5-Chloro-3-phenylbenzo[c]isoxazole, SMILES is ClC1=CC2=C(C3=CC=CC=C3)ON=C2C=C1, belongs to Benzisoxazole compound. In a document, author is STIFF, DD, introduce the new discover, Quality Control of 5-Chloro-3-phenylbenzo[c]isoxazole.
REDUCTIVE METABOLISM OF THE ANTICONVULSANT AGENT ZONISAMIDE, A 1,2-BENZISOXAZOLE DERIVATIVE
1. The metabolism of zonisamide in vitro was characterized through aerobic and anaerobic incubations with rat liver subcellular fractions and cultured gastrointestinal microflora. 2. Zonisamide reacted with rat hepatic microsomal cytochrome P-450 and exhibited a Type I binding spectrum. 3. Metabolism of zonisamide in vitro by hepatic subcellular fractions and cultured gastrointestinal flora produced a single metabolite, 2-(sulphamoylacetyl)-phenol (2-SMAP), by reductive cleavage of the 1,2-benzisoxazole ring. 4. The reductive metabolism of zonisamide was primarily mediated by microsomal cytochrome P-450. The soluble fraction enhanced reduction when combined with the microsomal fraction but itself possessed only weak reductive activity. 5. Reduction of zonisamide by the most enzymically active liver fractions required NADPH, was stimulated by FMN and SKF-525A, and was inhibited by CO or air, as well as by n-octylamine. 6. Unlike their involvement in the reduction of numerous nitro, azo, and N-oxide compounds, cultured aerobic and anaerobic intestinal flora were not principally involved in the reduction of zonisamide.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 719-64-2 is helpful to your research. Quality Control of 5-Chloro-3-phenylbenzo[c]isoxazole.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics