36216-80-5, An article , which mentions 36216-80-5, molecular formula is C7H6N2O. The compound – Benzo[d]isoxazol-3-amine played an important role in people’s production and life.
?In-loop? [11C]CO2 fixation: Prototype and proof of concept
Carbon-11-labeled carbon dioxide is the most common feedstock for the synthesis of positron emission tomography radiotracers and can be directly used for 11C-carbonylation. Herein, we report the development of an apparatus that takes advantage of ?in-loop? technologies to facilitate robust and reproducible syntheses of 11C-carbonyl-based radiotracers by [11C]CO2-fixation. Our ?in-loop? [11C]CO2-fixation method is simple, efficient, and proceeds smoothly at ambient pressure and temperature. We selected model 11C-carbonyl-labeled carbamates as well as symmetrical and unsymmetrical ureas based on their widespread use in radiotracer design and our clinical research interests for proof of concept. Utility of this method is demonstrated by the synthesis of a reversible radiopharmaceutical for monoamine oxidase B, [11C]SL25.1188, and 2 novel fatty acid amide hydrolase inhibitors. These radiotracers were isolated and formulated (>3.5?GBq; 100?mCi) with radiochemical purities (>99%) and molar radioactivity (?80?GBq/mumol; ?2162?mCi/mumol).
36216-80-5, Interested yet? Read on for other articles about 36216-80-5!
Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics