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An improved, practical and efficient method for the synthesis of novel N-chloro derivatives using calcium hypochlorite
The developed method was employed in the synthesis of medicinally important compounds and intermediates in the organic synthesis. Herein we report a variety of novel N-chloro derivatives of benzisoxazole, benzimidazoles and several other N-chloro derivatives using 1.2 equivalents of calcium hypochlorite. The process does not require any additives like acids or bases and produced moderate to excellent yields of desired products under mild conditions.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics