So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Alhakamy, Nabil A.; Noor, Ahmad O.; Hosny, Khaled M.; Nasr, Jenny Jeehan; Fouda, Moustafa M. G.; Khattab, Tawfik A.; Gaffer, Hatem E. researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Quality Control of 2-Furoic hydrazide.They published the article 《Synthesis of New Cyanopyridine Scaffolds and their Biological Activities》 about this compound( cas:3326-71-4 ) in Current Organic Synthesis. Keywords: cyanopyridinylamino hydrazide preparation antibacterial antituberculosis antioxidant antitumor; chalcone cyanopyridinylamino preparation antibacterial antituberculosis antioxidant antitumor; cyanopyridinylaminophenyl cyanopyridinylamine preparation antibacterial antituberculosis antioxidant antitumor; 3-cyanopyridine; anti-tuberculosis; anticancer activity; antimicrobial; antioxidant; cytotoxicity. We’ll tell you more about this compound (cas:3326-71-4).
The 3-cyanopyridine analogs I, II and III [Ar = 4-methylphenyl, 4-methoxyphenyl, 4-chlorophenyl, etc.] were synthesized and examined to determine their activity against the M. tuberculosis H37Rv strain. Derivatives I [2-thienyl, 4-chlorophenyl] and II [Ar = 2-furyl, 2-thienyl]had good inhibition. Further screening was done for the highest potency against M. tuberculosis to determine the MICs. The antioxidant efficacy was evaluated via the DPPH technique matched with vitamin C as a pos. control. Some synthesized derivatives displayed good potency against bacterial activity and M tuberculosis. The antioxidant performance of these derivatives did not display scavenging efficacies compared to vitamin C. The cytotoxic activity of the synthesized derivatives was also examined various cell lines to display good cytotoxic activity in the order III > II > I.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics