Gu, Zheng-Song; Wang, Wen-Tao; Qian, Hao; Zhou, Ai-Nan; Sun, Hong-Bin; Zhang, Qing-Wei; Li, Jian-Qi published the artcile< Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT1A/5-HT7>, Recommanded Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, the main research area is aralkyl piperazine piperidine antidepressant SSRI 5HT1A 5HT7 target; 5-HT(1A) receptor; 5-HT(7) receptor; Antidepressant; Serotonin reuptake inhibition.
A series of novel aralkyl piperazine and piperidine derivatives were synthesized, and evaluated for their serotonin reuptake inhibitory and 5-HT1A/5-HT7 receptors affinities activity. Antidepressant activities in vivo of the selective compound were screened using the forced swimming test (FST) and tail suspension test (TST). The results indicated that compound 19a (I) exhibited high affinities for the 5-HT1A/5-HT7 receptors (5-HT1A, Ki = 12 nM; 5-HT7, Ki = 3.2 nM) coupled with potent serotonin reuptake inhibition (IC50 = 14 nM) and showed a marked antidepressant-like effect in the FST and TST models.
Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT reuptake inhibitors. 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Recommanded Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole.
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics