He, Ze-Liang; Zhang, Yi; Chen, Zhi-Chao; Du, Wei; Chen, Ying-Chun published the artcile< Cascade Multicomponent Assemblies Involving 1,3-Enynes via Auto-Tandem Palladium Catalysis>, Product Details of C12H13FN2O, the main research area is chromene preparation chemoselective regioselective diastereoselective; enyne carbonyl organoboronic reagent nucleophile cascade multicomponent palladium catalyst; dihydroquinoline preparation chemoselective regioselective diastereoselective; benzoxepine preparation chemoselective regioselective diastereoselective; annulated indole preparation chemoselective regioselective diastereoselective.
Here, a three-component auto-tandem reaction of 1,3-enyne-tethered carbonyls 2-R4C(O)-3-R-4-R1-5-R2-6-R3C6O(CH2)nCCCH=CH2 (R = H, Me; R1 = H, t-Bu, MeO; RR1 = -CH=CH-CH=CH-; R2 = H, Cl, Me; R3 = H, Cl; R4 = H, Me; n = 1, 2), organoboronic reagents R5B(OH)2 (R5 = Et, styryl, 2-naphthyl, benzofuran-3-yl, etc.), and suitable nucleophiles R6H [R6 = morpholino, methylbenzylamino, 2-hydroxy-1-naphthyl] catalyzed by palladium, proceeding through consecutive intramol. vinylogous addition, Suzuki coupling, and allylic alkylation was reported. This process exhibited high chemo- and regioselectivity with 1,3,4-trifunctionalization of the 1,3-enyne motif, and a wide range of 2H-chromenes and benzo[b]oxepine I, 1,2-dihydroquinoline II, 1,7-annulated indole III, and other frameworks was efficiently constructed in fair to good yields and E/Z selectivity.
Organic Letters published new progress about Addition reaction (vinylogous). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Product Details of C12H13FN2O.
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics