Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 6009-70-7, Name is Ammonium oxalate monohydrate, molecular formula is C2H10N2O5, belongs to Benzisoxazole compound, is a common compound. In a patnet, author is He, Guangchao, once mentioned the new application about 6009-70-7, Recommanded Product: Ammonium oxalate monohydrate.
Design, synthesis and biological evaluation of N-hydroxy- aminobenzyloxyarylamide analogues as novel selective kappa opioid receptor antagonists
Aminobenzyloxyarylamide derivatives la-i and 2a-t were designed and synthesized as novel selective kappa opioid receptor (KOR) antagonists. The benzoyl amide moiety of LY2456302 was changed into N-hydroxybenzamide and benzisoxazole-3(2H)-one to investigate whether it could increase the binding affinity or selectivity for KOR. All target compounds were evaluated in radioligand binding assays for opioid receptor binding affinity. These efforts led to the identification of compound lc (kappa K-i = 179.9 nM), which exhibited high affinity for KOR. Moreover, the selectivity of KOR over MOR and DOR increased nearly 2-fold and 7-fold, respectively, compared with ( +/- )LY2456302.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 6009-70-7. The above is the message from the blog manager. Recommanded Product: Ammonium oxalate monohydrate.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics