Electric Literature of C5H6N2O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides.
An oxidative sp3 C-H bond of methyl-azaheteroarenes protocol RCH3 (R = quinolin-2-yl, benzo[f]quinolin-3-yl, pyridin-2-yl, etc.) was reported for the synthesis of 1,3,4-oxadiazoles I (R1 = 2H-1,3-benzodioxol-5-yl, furan-2-yl, prop-1-en-2-yl, etc.) via [4+1] annulation with hydrazides R1C(O)NHNH2. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles I via selective oxidation of sp3 C-H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.
This literature about this compound(3326-71-4)Electric Literature of C5H6N2O2has given us a lot of inspiration, and I hope that the research on this compound(2-Furoic hydrazide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics