Weisz, Adrian; Idina, Ana; Ben-Ari, Julius; Karni, Miriam; Mandelbaum, Asher; Ito, Yoichiro published the article 《Preparative separation of isomeric and stereoisomeric dicarboxylic acids by pH-zone-refining counter-current chromatography》. Keywords: dicarboxylic acid isomeric stereoisomer pH zone refining countercurrent chromatog.They researched the compound: cis-Cyclohexane-1,2-dicarboxylic acid( cas:610-09-3 ).Name: cis-Cyclohexane-1,2-dicarboxylic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:610-09-3) here.
This work involves the preparative separation of some isomeric dicarboxylic acids using pH-zone-refining countercurrent chromatog. (CCC), a relatively new preparative technique for the separation of ionizable compounds The paper concentrates especially on the separation of a synthetic mixture of closely related cis and trans pairs of 1-methyl- and 1,3-dimethyl-1,3-cyclohexanedicarboxylic acids. The elution sequence of the isomers is discussed in terms of their relative acidities (pKa values) in solution and gas phase, hydrophobicities, and steric configuration. Two possible explanations are suggested for the mechanism of separation They both involve the amount of retainer acid used, as it affects the separation and plays a role in the chemohydrodynamic equilibrium of the dicarboxylic acids in the column.
There is still a lot of research devoted to this compound(SMILES：O=C([C@H]1[C@@H](C(O)=O)CCCC1)O)Name: cis-Cyclohexane-1,2-dicarboxylic acid, and with the development of science, more effects of this compound(610-09-3) can be discovered.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics