Li, Feng; Wu, Ziyan; Wang, Jingjing; Zhang, Siyuan; Yu, Jiaxin; Yuan, Zhen; Liu, Jingya; Shen, Renzeng; Zhou, Yao; Liu, Lantao published the artcile< Metal-free synthesis of N-sulfonylformamidines via skeletal reconstruction of sulfonyl oximonitriles>, Quality Control of 84163-77-9, the main research area is sulfonylformamidine preparation diastereoselective; secondary amine sulfonyl oximonitrile tandem reaction.
For the first time, an unprecedented domino reaction of sulfonyl oximonitriles C6H5CH2ON=C(CN)S(O)2Ar (Ar = Ph, 4-methylphenyl) with secondary amines such as morpholine, bis(propan-2-yl)amine, pyrrolidine, etc. to streamline the synthesis of N-sulfonylformamidines, e.g., I, in decent to high yields under mild reaction conditions was developed. In addition, scale-up experiments and late-stage functionalization of drugs were also performed. Preliminary studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction.
Organic Chemistry Frontiers published new progress about Benzenesulfonamides Role: SPN (Synthetic Preparation), PREP (Preparation). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Quality Control of 84163-77-9.
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics