In an article, author is MEWSHAW, RE, once mentioned the application of 3878-55-5, COA of Formula: C5H8O4, Name is 4-Methoxy-4-oxobutanoic acid, molecular formula is C5H8O4, molecular weight is 132.12, MDL number is MFCD00002788, category is Benzisoxazole. Now introduce a scientific discovery about this category.
EXAMINATION OF THE D(2)/5-HT(2) AFFINITY RATIOS OF RESOLVED 5,6,7,8,9,10-HEXAHYDRO-7,10-IMINOCYCLOHEPT[B]INDOLES – AN ENANTIOSELECTIVE APPROACH TOWARD THE DESIGN OF POTENTIAL ATYPICAL ANTIPSYCHOTICS
Enantiomers of several N-substituted 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles were obtained by the resolution of 2-fluoro-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole and 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole followed by N-alkylation. These, as well as the racemates, were evaluated for their affinity for the 5-HT2 and D2 receptors. Those compounds possessing the 7S,10R stereochemistry were consistently recognized by the 5-HT2 and D2 receptors as the eutomer. 2-Fluoro-11-[4-(4-fluorophenyl)-4-oxobutyl]-5,6,7,8,9,10-hexahydro-7S,10R-iminocyclohept[b]indole [(7S,10R)-8] had the highest affinity for the 5-HT2 receptor (K(i) = 0.80 nM), while its distomer (7R,10S)-8 was the most selective member of this class of bridged gamma-carbolines (D2/5-HT2 = 562). Incorporation of a benzoyl or isosteric benzisoxazole moiety tethered by a four-carbon spacer to a bridged gamma-carboline nucleus, possessing the 7S,10R absolute configuration, produced high affinity ligands for the 5-HT2 and D2 receptors.
If you are interested in 3878-55-5, you can contact me at any time and look forward to more communication. COA of Formula: C5H8O4.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics