Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 610-09-3, is researched, SMILESS is O=C([C@H]1[C@@H](C(O)=O)CCCC1)O, Molecular C8H12O4Journal, Article, Journal of Chromatography A called Preparative separation of isomeric and stereoisomeric dicarboxylic acids by pH-zone-refining counter-current chromatography, Author is Weisz, Adrian; Idina, Ana; Ben-Ari, Julius; Karni, Miriam; Mandelbaum, Asher; Ito, Yoichiro, the main research direction is dicarboxylic acid isomeric stereoisomer pH zone refining countercurrent chromatog.Product Details of 610-09-3.
This work involves the preparative separation of some isomeric dicarboxylic acids using pH-zone-refining countercurrent chromatog. (CCC), a relatively new preparative technique for the separation of ionizable compounds The paper concentrates especially on the separation of a synthetic mixture of closely related cis and trans pairs of 1-methyl- and 1,3-dimethyl-1,3-cyclohexanedicarboxylic acids. The elution sequence of the isomers is discussed in terms of their relative acidities (pKa values) in solution and gas phase, hydrophobicities, and steric configuration. Two possible explanations are suggested for the mechanism of separation They both involve the amount of retainer acid used, as it affects the separation and plays a role in the chemohydrodynamic equilibrium of the dicarboxylic acids in the column.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics