Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 75-98-9, Name is Pivalic acid, SMILES is CC(C)(C)C(O)=O, in an article , author is SATO, H, once mentioned of 75-98-9, Application In Synthesis of Pivalic acid.
STUDIES ON URICOSURIC DIURETICS .2. SUBSTITUTED 7,8-DIHYDROFURO[2,3-G]-1,2-BENZISOXAZOLE-7-CARBOXYLIC ACIDS AND 7,8-DIHYDROFURO[2,3-G]BENZOXAZOLE-7-CARBOXYLIC ACIDS
A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids 9 and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids 12 were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives 9 showed uricosuric and only weak diuretic activities, whereas the benzoxazoles 12 exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (9b, AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics